AA Chentoufi, C Polychronakos - Diabetes, 2002 - Am Diabetes Assoc Type 1 diabetes results from autoimmune destruction of the insulin-producing
pancreatic β-cells. Evidence from our laboratory and others has suggested that
the IDDM2 locus determines diabetes susceptibility by modulating levels of ... Cited by 126 - Related articles - BL Direct - All 4 versions
- ►nih.gov K Thébault-Baumont, D Dubois-Laforgue, P … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Accumulating evidence favors a role for proinsulin as a key autoantigen in
diabetes. In the mouse, two proinsulin isoforms coexist. Most studies point to
proinsulin 2 as the major isoform recognized by T cells in the NOD mouse. ... Cited by 102 - Related articles - BL Direct - All 6 versions
P Vafiadis, ST Bennett, JA Todd, J Nadeau, … - Nature genetics, 1997 - nature.com 1 The McGill University-Montreal Children's Hospital Research Institute and the
Department of Pediatrics, Division of Endocrinology, McGill University,
Montréal, Québec, Canada H3H1P3. ... 2 The Wellcome Trust Centre for ... Cited by 440 - Related articles - BL Direct - All 4 versions
- ►nih.gov H Moriyama, N Abiru, J Paronen, K Sikora, E … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences It has been reported that an insulin 2 gene knockout, when bred onto nonobese
diabetic (NOD) mice, accelerates diabetes. We produced insulin 1 gene knockout
congenic NOD mice. In contrast to insulin 2, diabetes and insulitis were ... Cited by 79 - Related articles - BL Direct - All 10 versions
- ►nih.gov A Pugliese, D Brown, D Garza, D Murchison, M … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Recent reports indicate that genes with tissue-restricted expression, including
those encoding the type 1 diabetes autoantigens insulin, glutamic acid
decarboxylase (GAD), and the tyrosine-phosphatase-like protein IA-2 (or ... Cited by 105 - Related articles - BL Direct - All 9 versions
- ►endojournals.org M Throsby, F Homo-Delarche, D Chevenne, R … - Endocrinology, 1998 - Endocrine Soc The expression of preproinsulin (ppIns), proglucagon, prosomatostatin, and
propancreatic polypeptide was investigated in thymic extracts, thymic cells, and
thymic cell lines from C57BL/6 mice by RT-PCR. The expression of pancreatic ... Cited by 79 - Related articles - BL Direct - All 5 versions
MK Brimnes, T Jensen, TN Jørgensen, BK … - Journal of Autoimmunity, 2002 - Elsevier Insulin is a predominant autoantigen in IDDM in man and the NOD mouse. Failure
of negative selection of diabetogenic T cells in thymus may be an important
pre-disposing cause of the disease. To obtain insight into negative ... Cited by 16 - Related articles - BL Direct - All 5 versions
W Chen, I Bergerot, JF Elliott, LC Harrison, N … - The Journal of Immunology, 2001 - Am Assoc Immnol The expression of pro(insulin) in the thymus may lead to the negative selection
of pro(insulin) autoreactive T cells and peripheral tolerance to this
autoantigen in type 1 diabetes (T1D). We investigated whether proinsulin is ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►endojournals.org P Vafiadis, H Ounissi-Benkalha, M Palumbo, … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc Type 1 diabetes results from autoimmune destruction of the insulin-producing
pancreatic ß cells. The insulin gene (INS) is also expressed in human thymus,
an ectopic expression site likely involved in immune tolerance. The IDDM2 ... Cited by 43 - Related articles - BL Direct - All 4 versions
