M Nakayama, M Nagata, H Yasuda, K Arisawa, R … - Diabetes, 2002 - Am Diabetes Assoc Apoptosis via Fas/Fas ligand (FasL) interactions has been proposed to be a major T-cell-mediated
effector mechanism in autoimmune diabetes. To elucidate the role of Fas/FasL interactions in
NOD diabetes, the effects of neutralizing anti-FasL antibody on autoimmune responses ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►pnas.org AY Savinov, A Tcherepanov, EA Green, … - Proceedings of the …, 2003 - National Acad Sciences Fas (Tnfrsf6, Apo-1, CD95) is a death receptor involved in apoptosis induced in many cell
types. Fas have been shown to be expressed by insulin-producing beta cells in mice and
humans. However, the importance of Fas in the development of autoimmune diabetes ... Cited by 60 - Related articles - BL Direct - All 9 versions
N Petrovsky, D Silva, L Socha, R Slattery, … - ANNALS-NEW YORK …, 2002 - interscience.wiley.com Abstract: Fas ligand (FasL), a type 2 membrane protein belonging to the TNF family, plays an
important role in the induction of cell death. Ligation of Fas receptors by FasL results in apoptosis
of the Fas-expressing cell. Autoimmune diabetes results from β cell destruction by islet- ... Cited by 33 - Related articles - BL Direct - All 3 versions
WL Suarez-Pinzon, RF Power, A Rabinovitch - Diabetologia, 2000 - Springer A variety of immune system cells, including macro- phages, CD4 + T cells and CD8 + T cells
have been im- plicated as mediators of pancreatic islet beta-cell de- struction in Type I
(insulin-dependent)diabetes mel- litus. One of the mechanisms of T-cell cytotoxicity is a ... Cited by 35 - Related articles - BL Direct - All 3 versions
- ►rupress.org I Apostolou, Z Hao, K Rajewsky, H von … - Journal of Experimental …, 2003 - jem.rupress.org In type 1 diabetes, autoimmune T cells cause destruction of pancreatic ß cells by largely unknown
mechanism. Previous analyses have shown that ß cell destruction is delayed but can occur in
perforin-deficient nonobese diabetic (NOD) mice and that Fas-deficient NOD mice do not ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►pnas.org J Allison, A Strasser - Proceedings of the National Academy of …, 1998 - National Acad Sciences Insulin-dependent diabetes mellitus is an autoimmune disease, under polygenic control, manifested
only when >90% of the insulin-producing β cells are destroyed. Although the disease is T cell
mediated, the demise of the β cell results from a number of different insults from the ... Cited by 83 - Related articles - BL Direct - All 8 versions
- ►nih.gov A Amrani, J Verdaguer, S Thiessen, S Bou, … - Journal of Clinical …, 2000 - Am Soc Clin Investig Cytokines such as IL-1α, IL-1β, and IFN-γ have long been implicated in the pathogenesis of autoimmune
diabetes, but the mechanisms through which they promote diabetogenesis remain unclear. Here
we show that CD4 + T lymphocytes propagated from transgenic nonobese diabetic (NOD) ... Cited by 84 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org R Darwiche, MMW Chong, P Santamaria, HE … - The Journal of …, 2003 - Am Assoc Immnol Fas (CD95) is a potential mechanism of pancreatic cell death in type 1 diabetes. cells do not
constitutively express Fas but it is induced by cytokines. The hypothesis of this study is that Fas
expression should be measurable on cells for them to be killed by this mechanism. We ... Cited by 24 - Related articles - BL Direct - All 4 versions
- ►nih.gov A Amrani, J Verdaguer, B Anderson, T … - Journal of Clinical …, 1999 - Am Soc Clin Investig Autoimmune diabetes in nonobese diabetic (NOD) mice results from destruction of pancreatic
β cells by T lymphocytes. It is believed that CD8 + cytotoxic T lymphocytes (CTLs) effect the initial
β-cell insult in diabetes, but the mechanisms remain unclear. Studies of NOD.lpr mice ... Cited by 79 - Related articles - BL Direct - All 6 versions
L Vence, C Benoist, D Mathis - Diabetes, 2004 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease wherein autoreactive T-cells promote the specific
destruction of pancreatic islet β-cells. Evidence for a crucial role for Fas/FasL interactions in this
destruction has been highly controversial because of the pleiotropic effects of Fas ... Cited by 11 - Related articles - BL Direct - All 5 versions
