- ►diabetesjournals.org H Kojima, T Nakamura, Y Fujita, A Kishi, M Fujimiya, S … - Diabetes, 2002 - Am Diabetes Assoc Immature rat intestinal stem cells (IEC-6) given the ability to express the transcription factor, pancreatic
duodenal homeobox 1 (Pdx-1), yielded YK cells. Although these cells produced multiple enteroendocrine
hormones, they did not produce insulin. Exposure of YK cells to 2 nmol/l betacellulin ... Cited by 111 - Related articles - BL Direct - All 5 versions
S Yoshida, Y Kajimoto, T Yasuda, H Watada, Y Fujitani, … - Diabetes, 2002 - Am Diabetes Assoc A homeodomain containing transcription factor PDX-1 can induce β-cell–specific gene expressions
in some non–β-cells and may therefore be useful for future diabetes gene/cell therapy. Among
the potential target organs or tissues for transcription factor–mediated induction of ... Cited by 91 - Related articles - BL Direct - All 5 versions
H Kojima, M Fujimiya, K Matsumura, P Younan, H … - Nature medicine, 2003 - nature.com To explore induced islet neogenesis in the liver as a strategy for the treatment of diabetes, we
used helper-dependent adenovirus (HDAD) to deliver the pancreatic duodenal homeobox-1
gene (Ipf1; also known as Pdx-1) to streptozotocin (STZ)-treated diabetic mice. HDAD is ... Cited by 236 - Related articles - BL Direct - All 3 versions
S Ferber, A Halkin, H Cohen, I Ber, Y Einav, I … - Nature medicine, 2000 - ntbiomol.unibe.ch Insulin gene expression is restricted to islet β cells of the mam- malian pancreas through specific
control mechanisms mediated in part by specific transcription factors1,2. The protein encoded
by the pancreatic and duodenal homeobox gene 1 (PDX-1) is central in regulating ... Cited by 389 - Related articles - View as HTML - BL Direct - All 3 versions
- ►montreal-diabetes-research-center.org [PDF] ME Horb, CN Shen, D Tosh, JMW Slack - Current Biology, 2003 - Elsevier Results: We show that a modified form of Pdx1, carrying the VP16 transcriptional activation
domain, can cause conversion of liver to pancreas, both in vivo and in vitro. Transgenic Xenopus
tadpoles carrying the construct TTR-Xlhbox8-VP16:Elas-GFP were prepared. Xlhbox8 is ... Cited by 180 - Related articles - All 17 versions
M Zalzman, S Gupta, RK Giri, I Berkovich, … - Proceedings of the …, 2003 - National Acad Sciences Beta-cell replacement is considered to be the most promising approach for treatment of type
1 diabetes. Its application on a large scale is hindered by a shortage of cells for
transplantation. Activation of insulin expression, storage, and regulated secretion in stem/ ... Cited by 171 - Related articles - BL Direct - All 13 versions
T Miyatsuka, H Kaneto, Y Kajimoto, S Hirota, Y … - … and Biophysical Research …, 2003 - Elsevier To date, the potency of pancreatic and duodenal homeobox gene 1 (PDX-1) in inducing differentiation
into insulin-producing cells has been demonstrated in some cells and tissues. In order to carry
out efficient screening of somatic tissues and cells that can transdifferentiate into ... Cited by 46 - Related articles - All 6 versions
H Taniguchi, E Yamato, F Tashiro, H Ikegami, T … - Gene Therapy, 2003 - nature.com -cell neogenesis is expected to provide a new therapy for diabetes. Numerous studies have demonstrated
that transcriptional regulation involving pdx-1 is essential for endocrine neogenesis in vivo and
in vitro. Therefore, it is possible that ectopic expression of pdx-1 in the pancreas could ... Cited by 56 - Related articles - BL Direct - All 4 versions
I Ber, K Shternhall, S Perl, Z Ohanuna, I Goldberg, I … - Journal of Biological …, 2003 - ASBMB Pancreatic and duodenal homeobox gene-1 (PDX-1) regulates pancreas development during
embryogenesis, whereas in the adult it controls β-cell function. Here we analyze whether
PDX-1 functions as a pancreatic differentiation factor and a bona fide master regulator ... Cited by 106 - Related articles - BL Direct - All 4 versions
A Suzuki, H Nakauchi, H Taniguchi - Proceedings of the …, 2003 - National Acad Sciences Glucagon-like peptide (GLP) 1 is produced through posttranslational processing of proglucagon
and acts as a regulator of various homeostatic events. Among its analogs, however, the function
of GLP-1-(1–37), synthesized in small amounts in the pancreas, has been unclear. Here, ... Cited by 68 - Related articles - All 9 versions
