P Marchetti, R Lupi, M Federici, L Marselli, M Masini, U … - Diabetes, 2002 - Am Diabetes Assoc Type 2 (non–insulin-dependent) diabetes results from decreased insulin action in peripheral
target tissues (insulin resistance) and impaired pancreatic β-cell function. These defects reflect
both genetic components and environmental risk factors. Recently, the common Gly 972 ... Cited by 67 - Related articles - BL Direct - All 5 versions
P Marchetti, R Lupi, M Federici, L Marselli, M Masini, U … - Diabetes, 2002 - Am Diabetes Assoc Page 1. Brief Genetics Report Insulin Secretory Function Is Impaired in Isolated Human
Islets Carrying the Gly 972 3Arg IRS-1 Polymorphism Piero Marchetti, 1 Roberto Lupi, 1
Massimo Federici, 2 Lorella Marselli, 1 Matilde Masini, 4 Ugo Boggi, 4 ... Cited by 13 - Related articles
M Stumvoll, A Fritsche, A Volk, N Stefan, A Madaus, E … - Diabetes, 2001 - Am Diabetes Assoc The Gly972Arg polymorphism in the insulin receptor substrate (IRS)-1 was found in some studies
to have a higher prevalence in type 2 diabetic subjects than in control subjects. Previously, transfection
of IRS-1 with this polymorphism into insulin-secreting cells resulted in a marked reduction ... Cited by 58 - Related articles - BL Direct - All 4 versions
- ►nih.gov O Porzio, M Federici, ML Hribal, D Lauro, D … - Journal of Clinical …, 1999 - Am Soc Clin Investig Recent studies have identified several polymorphisms in the human insulin receptor
substrate-1 (IRS-1) gene. The most prevalent IRS-1 variant, a Gly→Arg change at the codon
972, has been reported to be increased in prevalence among patients with type 2 ... Cited by 116 - Related articles - BL Direct - All 8 versions
- ►fasebj.org [PDF] M Federici, ML Hribal, M Ranalli, L Marselli, O Porzio, … - The FASEB Journal, 2000 - FASEB * Laboratory of Molecular Medicine, Department of Internal Medicine, University of Rome-«Tor
Vergata», 00133 Rome, Italy; †IDI-IRCCS, Biochemistry Laboratory, c/o Department of Experimental
Medicine, University of Rome-«Tor Vergata», Rome, Italy; and ‡Department of ... Cited by 73 - Related articles - All 3 versions
R Lupi, S Del Guerra, C Tellini, R Giannarelli, A … - European journal of …, 1999 - Elsevier Pancreatic islet desensitization by high glucose concentrations is a temporary and reversible
state of beta-cell refractoriness to glucose (and possibly other secretagogues), due to repeated
or prolonged pre-exposure to increased glucose concentrations. We evaluated whether ... Cited by 28 - Related articles - All 5 versions
A Jellema, MPA Zeegers, EJM Feskens, PC Dagnelie, … - Diabetologia, 2003 - Springer Aims/hypothesis. Several case-control studies have ex- amined the association between the
Gly972Arg variant in the IRS-1 gene and Type 2 diabetes, but most had limited power and results
could therefore be conflict- ing. Methods. We systematically reviewed the literature by ... Cited by 75 - Related articles - BL Direct - All 5 versions
Y Zhang, N Wat, IM Stratton, MG Warren-Perry, M Orho, … - Diabetologia, 1996 - Springer The common form of late-onset non-insulin-depen- dent diabetes mellitus (NIDDM) is a complex
disor- der in which at least two major defects contribute to the pathophysiology of the
phenotype: insulin defi- ciency and insulin resistance [1–3]. It is likely that NIDDM is ... Cited by 89 - Related articles - BL Direct - All 13 versions
- ►endojournals.org ML Hribal, M Federici, O Porzio, D Lauro, P … - Journal of Clinical …, 2000 - Endocrine Soc Molecular scanning of insulin receptor substrate-1 (IRS-1) revealed several amino acid
substitutions. The most common IRS-1 variant, a Gly to Arg 972 change, is more prevalent among
type 2 diabetic patients. In this study we overexpressed wild-type and Arg 972 IRS-1 ... Cited by 54 - Related articles - BL Direct - All 4 versions
GG Xu, ZY Gao, PD Borge Jr, PA Jegier, RA Young, BA … - Biochemistry, 2000 - ncbi.nlm.nih.gov The insulin receptor signaling pathway is present in beta-cells and is believed to be important
in beta-cell function. We show here that insulin directly regulates beta-cell function in isolated
rodent islets. Long-term insulin treatment caused a sustained increase in [Ca(2+)](i) and ... Cited by 41 - Related articles - BL Direct - All 3 versions
