R Lupi, F Dotta, L Marselli, S Del Guerra, M Masini, C … - Diabetes, 2002 - Am Diabetes Assoc In an effort to better understand the phenomenon of lipotoxicity in human β-cells, we evaluated
the effects of 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA) (2:1 oleate to
palmitate) on the function and survival of isolated human islets and investigated some of ... Cited by 270 - Related articles - BL Direct - All 7 versions
K Maedler, GA Spinas, D Dyntar, W Moritz, N Kaiser, … - Diabetes, 2001 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function observed in type 2
diabetes. Here we examine the effect of saturated and unsaturated fatty acids at different glucose
concentrations on β-cell proliferation and apoptosis. Adult rat pancreatic islets were ... Cited by 223 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org M Cnop, JC Hannaert, A Hoorens, DL Eizirik, DG … - Diabetes, 2001 - Am Diabetes Assoc Studies in Zucker diabetic fatty rats have led to the concept that chronically elevated free fatty
acid (FFA) levels can cause apoptosis of triglyceride-laden pancreatic β-cells as a result of the
formation of ceramides, which induce nitric oxide (NO)-dependent cell death. This “ ... Cited by 219 - Related articles - BL Direct - All 9 versions
S Piro, M Anello, C Di Pietro, MN Lizzio, G Patan, AM … - Metabolism, 2002 - Elsevier We investigated the effect of a chronic exposure to high levels of free fatty acid (FFA; 2
mmol/L oleate/palmitate 2:1) or glucose (16.7 mmol/L) on islet cell apoptosis. Apoptosis was
detected using 4 different methods: (1) cell staining with annexin-V fluorescien ... Cited by 122 - Related articles - BL Direct - All 7 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R Roduit, S … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs)
together with hyperglycemia are synergistic in causing islet ß-cell damage because high glucose
inhibits fat oxidation and consequently lipid detoxification. The effects of 1–2 d culture of ... Cited by 174 - Related articles - BL Direct - All 5 versions
- ►endojournals.org I Maestre, J Jordan, S Calvo, JA Reig, V Cena, B Soria, … - Endocrinology, 2003 - Endocrine Soc The potential toxic effects of high extracellular concentrations of fatty acids were tested in
ß(INS-1)-cells cultured in the absence of serum, a condition known to alter cell survival in various
systems. This may in part mimic the situation in type 1 or 2 diabetes where ß-cells are ... Cited by 82 - Related articles - BL Direct - All 8 versions
K Maedler, J Oberholzer, P Bucher, GA Spinas, MY … - Diabetes, 2003 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function observed in type 2
diabetes. Here we examine the effect of saturated and monounsaturated fatty acids at different
glucose concentrations on human β-cell turnover and secretory function. Exposure of ... Cited by 150 - Related articles - BL Direct - All 5 versions
M Shimabukuro, YT Zhou, M Levi, RH … - Proceedings of the …, 1998 - National Acad Sciences Like obese humans, Zucker diabetic fatty (ZDF) rats exhibit early β cell compensation for insulin
resistance (4-fold β cell hyperplasia) followed by decompensation (>50% loss of β cells). In prediabetic
and diabetic ZDF islets, apoptosis measured by DNA laddering is increased 3- and ... Cited by 644 - Related articles - BL Direct - All 13 versions
M Shimabukuro, M Higa, YT Zhou, MY Wang, CB … - Journal of Biological …, 1998 - ASBMB We reported that the lipoapoptosis of beta-cells observed in fat-laden islets of obese fa/fa Zucker
Diabetic Fatty (ZDF) rats results from overproduction of ceramide, an initiator of the apoptotic
cascade and is induced by long-chain fatty acids (FA). Whereas the ceramide of cytokine- ... Cited by 193 - Related articles - BL Direct - All 7 versions
YP Zhou, V Grill - Journal of Clinical Endocrinology & Metabolism, 1995 - Endocrine Soc Page 1. 0021-972w95/$03.00/0 Journal of Clinical Endocrinology and Metabolism Copyright
0 1995 by The Endocrine Society Vol. 80, No. 5 Printed in USA Long Term Exposure to Fatty
Acids and Ketones Inhibits B-Cell Functions in Human Pancreatic Islets of Lagerhans* ... Cited by 142 - Related articles - BL Direct - All 5 versions
