- ►diabetesjournals.org C Tourrel, D Bailbe, M Lacorne, MJ Meile, M … - Diabetes, 2002 - Am Diabetes Assoc In the Goto-Kakizaki (GK) rat, a genetic model of type 2 diabetes, the neonatal
β-cell mass deficit is considered to be the primary defect leading to basal
hyperglycemia, which is detectable for the first time 3 weeks after birth. ... Cited by 152 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org C Tourrel, D Bailbé, MJ Meile, M Kergoat, B … - Diabetes, 2001 - Am Diabetes Assoc In neonatal Wistar rats injected with streptozotocin (STZ) at birth (n0-STZ
model), a recognized model of β-cell regeneration, we investigated the capacity
of early treatment with glucagon-like peptide 1 (GLP-1) or exendin-4 to ... Cited by 173 - Related articles - BL Direct - All 5 versions
Q Wang, P Brubaker - Diabetologia, 2002 - Springer Aims/hypothesis. Glucagon-like peptide-1 ameliorates the symptoms of diabetes
through stimulation of insu- lin secretion and enhancement of beta-cell mass. We
have therefore investigated the effects of glucagon- like peptide-1 on the ... Cited by 138 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org DA Stoffers, BM Desai, DD DeLeon, RA … - Diabetes, 2003 - Am Diabetes Assoc Uteroplacental insufficiency resulting in fetal growth retardation is a common
complication of pregnancy and a significant cause of perinatal morbidity and
mortality. Epidemiological studies show an increased incidence of type 2 ... Cited by 90 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] G Xu, DA Stoffers, JF Habener, S Bonner-Weir - Diabetes, 1999 - Am Diabetes Assoc Diabetes is a disease of increasing prevalence in the general population and of
unknown cause. Diabetes is manifested as hyperglycemia due to a relative defi-
ciency of the production of insulin by the pancreatic -cells. One ... Cited by 515 - Related articles - All 4 versions
Y Li, T Hansotia, B Yusta, F Ris, PA Halban, … - Journal of Biological Chemistry, 2003 - ASBMB Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion and augments β
cell mass via activation of β cell proliferation and islet neogenesis. We
examined whether GLP-1 receptor signaling modifies the cellular ... Cited by 254 - Related articles - BL Direct - All 7 versions
- ►endojournals.org M Szayna, ME Doyle, JA Betkey, HW … - Endocrinology, 2000 - Endocrine Soc Exendin-4 is a 39 amino acid peptide produced in the salivary gland of the Gila
monster lizard. It has a 53% amino acid homology to the incretin hormone
glucagon-like peptide-1 (GLP-1). Exendin-4 induces insulin release through ... Cited by 195 - Related articles - BL Direct - All 2 versions
- ►endojournals.org JM Egan, AR Clocquet, D Elahi - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Exendin-4 is a potent and long-acting agonist of the glucagon-like peptide-1
(GLP-1) receptor. GLP-1 is an insulinotropic gut peptide and is being evaluated
for the regulation of plasma glucose in type 2 diabetes. The purpose of the ... Cited by 161 - Related articles - BL Direct - All 4 versions
- ►physiology.org JM Egan, GS Meneilly, D Elahi - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc A gut insulinotropic peptide, glucagon-like peptide-1 (GLP-1), when given
continuously subcutaneously, has been shown to be an effective agent to treat
type 2 diabetes. Because of inactivation by dipeptidyl peptidase IV (DPP ... Cited by 80 - Related articles - BL Direct - All 4 versions
- ►endojournals.org R Perfetti, J Zhou, ME Doyle, JM Egan - Endocrinology, 2000 - Endocrine Soc Glucose homeostasis in mammals is maintained by insulin secretion from the
ß-cells of the islets of Langerhans. Type 2 diabetes results either from
primary ß-cell failure alone and/or a failure to secrete enough insulin to ... Cited by 191 - Related articles - BL Direct - All 3 versions
