B Sudre, P Broqua, RB White, D Ashworth, DM Evans, … - Diabetes, 2002 - Am Diabetes Assoc Acute suppression of dipeptidyl peptidase IV (DPP-IV) activity improves glucose tolerance in
the Zucker fatty rat, a rodent model of impaired glucose tolerance, through stabilization of
glucagon-like peptide (GLP)-1. This study describes the effects of a new and potent ... Cited by 106 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JA Pospisilik, SG Stafford, HU Demuth, CHS McIntosh, … - Diabetes, 2002 - Am Diabetes Assoc Upon release into circulation, the potent insulin secretagogues glucose-dependent insulinotropic
polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are rapidly cleaved and inactivated by
the enzyme dipeptidyl peptidase IV (DP IV). Long-term administration of specific DP IV ... Cited by 99 - Related articles - BL Direct - All 6 versions
JA Pospisilik, SG Stafford, HU Demuth, R Brownsey, W … - Diabetes, 2002 - Am Diabetes Assoc The incretins, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide
1 (GLP-1) are responsible for >50% of nutrient-stimulated insulin secretion. After being released
into the circulation, GIP and GLP-1 are rapidly inactivated by the circulating enzyme ... Cited by 135 - Related articles - BL Direct - All 6 versions
- ►eje-online.org [PDF] MK Reimer, JJ Holst, B Ahren - European Journal of Endocrinology, 2002 - EFES Objectives: Inhibitors of the glucagon-like peptide-1 (GLP-1)-degrading enzyme, dipeptidyl peptidase
IV (DPPIV), are being explored in the treatment of diabetes. We examined the long-term influence
of a selective, orally active inhibitor of DPPIV (NVP DPP728), in normal female C57BL/6J ... Cited by 107 - Related articles - BL Direct - All 9 versions
- ►pasteur.ac.ir [PDF] B Ahrén, JJ Holst, H Mårtensson, B Balkan - European journal of pharmacology, 2000 - Elsevier We explored whether inhibition of the enzyme dipeptidyl peptidase IV (DPP IV) increases endogenous
levels of glucagon-like peptide-1 (GLP-1) and improves glucose tolerance and insulin secretion
in mice. Glucose (150 mg) was administered through a gastric gavage with or without the ... Cited by 133 - Related articles - All 5 versions
B Balkan, L Kwasnik, R Miserendino, JJ Holst, X Li - Diabetologia, 1999 - Springer Control of prandial plasma concentrations of sub- strates, particularly glucose, is aided by
incretins. In- cretins are hormones released by the digestive tract in response to ingested nutrients
[1]. The role of in- cretins is to sensitize beta cells to stimulation by glu- Cited by 158 - Related articles - BL Direct - All 3 versions
BO Ahrén, E Simonsson, H Larsson, M Landin- … - Diabetes Care, 2002 - Am Diabetes Assoc OBJECTIVE—Glucagon-like peptide-1 (GLP-1) has been proposed as a new treatment modality
for type 2 diabetes. To circumvent the drawback of the short half-life of GLP-1, inhibitors of the
GLP-1–degrading enzyme dipeptidyl peptidase IV (DPP IV) have been examined. Such ... Cited by 276 - Related articles - BL Direct - All 7 versions
- ►endocrinology-journals.org [PDF] CF Deacon, S Wamberg, P Bie, TE Hughes, … - Journal of …, 2002 - Soc Endocrinology The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic
polypeptide (GIP) are degraded by dipeptidyl peptidase IV (DPP IV), thereby losing insulinotropic
activity. DPP IV inhibition reduces exogenous GLP-1 degradation, but the extent of ... Cited by 63 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org JA Pospisilik, J Martin, T Doty, JA Ehses, N Pamir, FC … - Diabetes, 2003 - Am Diabetes Assoc Recent studies into the physiology of the incretins glucose-dependent insulinotropic polypeptide
(GIP) and glucagon-like peptide-1 (GLP-1) have added stimulation of β-cell growth,
differentiation, and cell survival to well-documented, potent insulinotropic effects. ... Cited by 163 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org CF Deacon, P Danielsen, L Klarskov, M Olesen, JJ … - Diabetes, 2001 - Am Diabetes Assoc Glucose-dependent insulinotropic peptide (GIP) is known to be degraded by dipeptidyl peptidase
IV (DPP IV), forming an inactive metabolite, but the extent of the enzyme's role in regulating the
biological activity of GIP in vivo is still largely unknown. In nonfasted anesthetized pigs ... Cited by 88 - Related articles - BL Direct - All 6 versions
