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Scholar Results 1 - 10 of about 101 related to Hegarty: Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal.... (0.08 sec) 

Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of …


BD Hegarty, GJ Cooney, EW Kraegen, SM … - Diabetes, 2002 - Am Diabetes Assoc
In humans and animal models, increased lipid content of skeletal muscle is
strongly associated with insulin resistance. However, it is unclear whether this
accumulation is due to increased uptake or reduced utilization of fatty ...
Cited by 77 - Related articles - BL Direct - All 5 versions

Increased fatty acid uptake and altered fatty acid metabolism in insulin-resistant muscle of …


LP Turcotte, JR Swenberger, M Zavitz Tucker, … - Diabetes, 2001 - Am Diabetes Assoc
Altered muscle fatty acid (FA) metabolism may contribute to the presence of
muscle insulin resistance in the genetically obese Zucker rat. To determine
whether FA uptake and disposal are altered in insulin-resistant muscle, we ...
Cited by 42 - Related articles - BL Direct - All 5 versions

Development and initial evaluation of a novel method for assessing tissue-specific plasma free …

- jlr.org
ND Oakes, A Kjellstedt, GB Forsberg, T … - The Journal of Lipid Research, 1999 - ASBMB
We describe a method for assessing tissue-specific plasma free fatty acid (FFA)
utilization in vivo using a non-ß-oxidizable FFA analog, [9,10- 3 H]-(R)-2-
bromopalmitate ( 3 HR-BrP). Ideally 3 HR-BrP would be transported in ...
Cited by 33 - Related articles - BL Direct - All 6 versions

Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in Muscle

- shouxi.net
N Turner, CR Bruce, SM Beale, KL Hoehn, T … - Diabetes, 2007 - Am Diabetes Assoc
A reduced capacity for mitochondrial fatty acid oxidation in skeletal muscle has
been proposed as a major factor leading to the accumulation of intramuscular
lipids and their subsequent deleterious effects on insulin action. Here, we ...
Cited by 60 - Related articles - BL Direct - All 5 versions

Fatty acid transport and FAT/CD36 are increased in red but not in white skeletal muscle of …

- physiology.org
A Chabowski, JC Chatham, NN Tandon, J … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc
An increased rate of fatty acid transport into skeletal muscle has been has been
linked to the accumulation of intramuscular lipids and insulin resistance, and
red muscles are more susceptible than white muscles in developing fatty ...
Cited by 21 - Related articles - BL Direct - All 4 versions

Local factors modulate tissue-specific NEFA utilization


SM Furler, GJ Cooney, BD Hegarty, MY Lim- … - Diabetes, 2000 - Am Diabetes Assoc
Insulin-resistant states are associated with accumulation of muscle lipid,
suggesting an imbalance between lipid uptake and oxidation. We have employed a
new fatty-acid tracer [9,10- 3 H]-(R)-2-bromopalmitate ( 3 HR-BrP) to study ...
Cited by 19 - Related articles - BL Direct - All 5 versions

The role of intramuscular lipid in insulin resistance


BD Hegarty, SM Furler, J Ye, GJ Cooney, EW … - Acta Physiologica Scandinavica, 2003 - interscience.wiley.com
It is also possible that your web browser is not configured or not able to
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degraded, the site should continue to be functional. We recommend using the ...
Cited by 120 - Related articles - BL Direct - All 4 versions

Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with …

- fasebj.org [PDF] 
A Bonen, ML Parolin, GR Steinberg, J Calles … - The FASEB Journal, 2004 - FASEB
Page 1. The FASEB Journal express article 10.1096/fj.03-1065fje. Published online
May 7, 2004. Triacylglycerol accumulation in human obesity and type 2 ...
Cited by 131 - Related articles - BL Direct - All 7 versions

A modified high-fat diet induces insulin resistance in rat skeletal muscle but not adipocytes

- physiology.org
JJ Wilkes, A Bonen, RC Bell - American Journal of Physiology- Endocrinology And …, 1998 - Am Physiological Soc
We hypothesized that variation in dietary fatty acid composition in rats fed a
high-fat diet had tissue-specific effects on glucose uptake sufficient to
maintain normal glucose tolerance. Rats were fed one of three diets for 3 ...
Cited by 49 - Related articles - BL Direct - All 7 versions

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle …

- cell.com
TR Koves, JR Ussher, RC Noland, D Slentz, … - Cell metabolism, 2008 - Elsevier
Previous studies have suggested that insulin resistance develops secondary to
diminished fat oxidation and resultant accumulation of cytosolic lipid molecules
that impair insulin signaling. Contrary to this model, the present study ...
Cited by 119 - Related articles - All 9 versions


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