- ►diabetesjournals.org EH Serné, RG IJzerman, ROB Gans, R Nijveldt, G De … - Diabetes, 2002 - Am Diabetes Assoc It has been proposed that insulin-mediated changes in muscle perfusion modulate insulin-mediated
glucose uptake. However, the putative effects of insulin on the microcirculation that permit such
modulation have not been studied in humans. We examined the effects of systemic ... Cited by 63 - Related articles - BL Direct - All 9 versions
- ►oxfordjournals.org EH Serne, ROB Gans, JC ter Maaten … - Cardiovascular …, 2001 - cardiovascres.oxfordjournals.org Impaired microvascular function is a well-established abnormality that occurs in patients with
essential hypertension [1]. In many tissues of these patients a decreased number of capillaries
and arterioles, so-called microvascular rarefaction, can be demonstrated [1–4]. ... Cited by 45 - Related articles - All 6 versions
- ►ahajournals.org EH Serne, CDA Stehouwer, JC ter Maaten, PM ter Wee … - Circulation, 1999 - Am Heart Assoc Methods and Results—Blood pressure was measured by 24-hour ambulatory blood pressure
monitoring. Videomicroscopy was used to measure skin capillary density and capillary recruitment
after arterial occlusion. Skin blood flow responses after iontophoresis of acetylcholine and ... Cited by 148 - Related articles - BL Direct - All 4 versions
RT De Jongh, ADH Clark, RG IJzerman, EH Serne, G … - Diabetologia, 2004 - Springer Aims/hypothesis. Insulin possesses vasodilatory ac- tions that may be important in regulating
its access to insulin-sensitive tissues. Our study aims to directly measure changes in response
to insulin in the human skeletal muscle microcirculation. Measurement was by an ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Coggins, J Lindner, S Rattigan, L Jahn, E Fasy, S … - Diabetes, 2001 - Am Diabetes Assoc Despite intensive study, the relation between insulin's action on blood flow and glucose metabolism
remains unclear. Insulin-induced changes in microvascular perfusion, independent from effects
on total blood flow, could be an important variable contributing to insulin's metabolic ... Cited by 97 - Related articles - BL Direct - All 5 versions
ADH Clark, EJ Barrett, S Rattigan, MG Wallis, … - Clinical …, 2001 - cs.portlandpress.com Insulin-mediated increases in limb blood flow are thought to enhance glucose uptake by skeletal
muscle. Using the perfused rat hindlimb, we report that macro laser Doppler flowmetry (LDF)
probes positioned on the surface of muscle detect changes in muscle capillary (nutritive) ... Cited by 41 - Related articles - Cached - BL Direct - All 11 versions
- ►physiology.org MG Clark, MG Wallis, EJ Barrett, MA … - American Journal of …, 2003 - Am Physiological Soc The vascular system controls the delivery of nutrients and hormones to muscle, and a number
of hormones may act to regulate muscle metabolism and contractile performance by modulating
blood flow to and within muscle. This review examines evidence that insulin has major ... Cited by 146 - Related articles - BL Direct - All 4 versions
LH Clerk, S Rattigan, MG Clark - Diabetes, 2002 - Am Diabetes Assoc Infusion of triglycerides and heparin causes insulin resistance in muscle. Because the vascular
actions of insulin, particularly capillary recruitment, may contribute to the increase in glucose
uptake by skeletal muscle, we investigated the effects of Intralipid/heparin infusion on the ... Cited by 76 - Related articles - BL Direct - All 5 versions
S Rattigan, MG Clark, EJ Barrett - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc Insulin-mediated changes in blood flow are associated with altered blood flow distribution and
increased cap- illary recruitment in skeletal muscle. Studies in per- fused rat hindlimb have shown
that muscle metabolism can be regulated by vasoactive agents that control blood flow ... Cited by 62 - Related articles - BL Direct - All 6 versions
- ►ahajournals.org EH Serne, ROB Gans, JC ter Maaten, GJ Tangelder, … - Hypertension, 2001 - Am Heart Assoc Abstract—— Capillary rarefaction occurs in many tissues in patients with essential hypertension
and may contribute to an increased vascular resistance and impaired muscle metabolism. Rarefaction
may be caused by a structural (anatomic) absence of capillaries, functional nonperfusion, ... Cited by 74 - Related articles - BL Direct - All 4 versions
