M Kakimoto, T Inoguchi, T Sonta, HY Yu, M … - Diabetes, 2002 - Am Diabetes Assoc Oxidative stress may contribute to the pathogenesis of diabetic nephropathy.
However, the detailed molecular mechanism remains uncertain. Here, we report
oxidative mitochondrial DNA (mtDNA) damage and accumulation of mtDNA with a ... Cited by 60 - Related articles - BL Direct - All 5 versions
S Suzuki, Y Hinokio, K Komatu, M Ohtomo, M … - Diabetes research and clinical practice, 1999 - Elsevier Increased oxidative stress induced by hyperglycemia may contribute to the
pathogenesis of diabetic complications. Oxidative stress is known to increase
the conversion of deoxyguanosine (dG) to 8-hydroxydeoxyguanosine (8-OHdG) ... Cited by 66 - Related articles - All 7 versions
H Ha, C Kim, Y Son, MH Chung, KH Kim - Free radical biology & medicine, 1994 - ncbi.nlm.nih.gov 8-Hydroxydeoxyguanosine (8-OHdG), an oxygen radical induced modification of
purine residue in DNA, was measured in the liver, pancreas, and kidney of
streptozotocin-induced diabetic rats (STZR) exhibiting microalbuminuria. At ... Cited by 64 - Related articles - BL Direct - All 2 versions
T Nishikawa, T Sasahara, S Kiritoshi, K … - Diabetes Care, 2003 - Am Diabetes Assoc RESULTS—The urinary 8-OHdG:creatinine ratio (U8-OHdG) was 2.5-fold higher in
patients with increased HbA 1c than in those with normal HbA 1c (P < 0.05). In
addition, U8-OHdG was 2.3-fold higher in patients with increased IMT (P < ... Cited by 56 - Related articles - BL Direct - All 5 versions
Y Hinokio, S Suzuki, M Hirai, M Chiba, A Hirai … - Diabetologia, 1999 - Springer Aims/hypothesis.Augmentedoxidativestressinduced by hyperglycaemia possibly
contributes to the patho- genesis of diabetic complications. Oxidative stress is
known to increase the conversion of deoxyguanosine to 8-oxo, 2 ... Cited by 78 - Related articles - BL Direct - All 5 versions
Y Hinokio, S Suzuki, M Hirai, C Suzuki, M … - Diabetologia, 2002 - Springer Aims/hypothesis. The increased oxidative stress in dia- betes is known to
contribute to the progression of dia- betes and its complications. We have
reported a signif- icant relation between the content of 8-oxo-7,8-dihy- ... Cited by 34 - Related articles - BL Direct - All 3 versions
T Sano, F Umeda, T Hashimoto, H Nawata, H … - Diabetologia, 1998 - Springer The generation of reactive oxygen species and free radicals has been shown to be
increased in patients with diabetes mellitus [1, 2]. Free radicals generated
through glycation may accelerate oxidation reactions in the vascular walls, ... Cited by 103 - Related articles - BL Direct - All 4 versions
KS Park, JH Kim, MS Kim, JM Kim, SK Kim, … - Diabetes, 2001 - Am Diabetes Assoc Cumulating evidence suggests that enhanced oxidative stress may contribute to
diabetic angiopathy. The levels of 8-hydroxydeoxyguanosine (8-OHdG) and
8-hydroxyguanine (8-OHG), indicators of oxidative DNA damage, in tissue or ... Cited by 45 - Related articles - BL Direct - All 6 versions
J Leinonen, T Lehtimäki, S Toyokuni, K Okada … - FEBS letters, 1997 - Elsevier Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) has been reported to serve as a
sensitive biomarker of oxidative DNA damage and also of oxidative stress. We
have investigated oxidative DNA damage in patients with ... Cited by 164 - Related articles - All 6 versions
T Etoh, T Inoguchi, M Kakimoto, N Sonoda, K … - Diabetologia, 2003 - Springer Aim/hypothesis. An increased production of reactive oxygen species (ROS) could
contribute to the devel- opment of diabetic nephropathy. NAD(P)H oxidase might
be an important source of ROS production in kidney as reported in blood ... Cited by 79 - Related articles - BL Direct - All 3 versions
