L Nisticò, G Giorgi, M Giordano, A Galgani, A Petrone, … - Diabetes, 2002 - Am Diabetes Assoc Linkage with chromosome 5q33–34 was recently detected in 249 sib-pairs from 187 British and
Australian multiplex families (5). Two noncoding polymorphisms of the interleukin 12B
(IL12B) gene, mapping in the linked region, were strongly associated (P = 10 −5 ) with the ... Cited by 19 - Related articles - BL Direct - All 6 versions
S Johansson, BA Lie, E Thorsby, DE Undlien - Immunogenetics, 2001 - Springer Type 1 diabetes (T1DM) is a multifactorial disease and both genetic and environmental factors
contribute to the pathogenesis. The HLA complex (IDDM1) encodes a major part of the genetic
predisposition, but a number of other genes, mostly unknown, elsewhere in the genome ... Cited by 15 - Related articles - BL Direct - All 3 versions
RM McCormack, AP Maxwell, DJ Carson, CC … - Genes and …, 2002 - ncbi.nlm.nih.gov A recent study employing Australian and UK type 1 diabetes families has demonstrated significant
transmission bias to affected offspring of a polymorphism (1188A allele; termed allele 1) in the
3' untranslated region (3'UTR) of the interleukin 12B (IL12B) gene which encodes the IL- ... Cited by 21 - Related articles - BL Direct
- ►bmj.com R Bergholdt, P Ghandil, J Johannesen, OP … - British Medical …, 2004 - jmg.bmj.com Confirmation of the significance of the IL12B 3'UTR polymorphism in T1DM in other populations
is important. The aims of our study were to seek confirmation of the involvement of the IL12B
C1159A SNP in T1DM susceptibility in a population based Danish family collection of 337 ... Cited by 22 - Related articles - All 5 versions
P Holm, H Luthman, I Kockum - ANNALS-NEW YORK …, 2003 - interscience.wiley.com Abstract: Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the β cells in the
pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological
situations, such as septic shock, tissue damage during inflammation, and organ-specific ... Cited by 4 - Related articles - BL Direct - All 5 versions
A Davoodi-Semiromi, JJ Yang, JX She - Diabetes, 2002 - Am Diabetes Assoc The IL-12p40 locus has recently been shown to be associated with type 1 diabetes (1).
Here, we report the identification of novel microsatellite and single-nucleotide polymorphisms
(SNPs) within the IL-12p40 gene and a significant association between a (ATT)n repeat ... Cited by 40 - Related articles - BL Direct - All 4 versions
L Windsor, G Morahan, D Huang, V McCann, T Jones, I … - Human immunology, 2004 - Elsevier Carriage of a polymorphism in the 3′untranslated region of the IL12B gene encoding IL-12p40
was investigated in subjects with type 1 diabetes mellitus stratified by age at diagnosis (n =
648) and compared with a population-based control cohort (n = 246) residing in Western ... Cited by 23 - Related articles - All 3 versions
JM Yang, S Nagasaka, T Yatagai, T Nakamura, I … - Diabetes research and …, 2006 - Elsevier The present study was undertaken to clarify a role of interleukin-12p40 gene (IL-12B)
polymorphism, located on chromosome 5q33-34 (IDDM 18), in Japanese subjects with Type
1 diabetes mellitus (T1DM) and autoimmune thyroid diseases (AITD). In 179 subjects with ... Cited by 4 - Related articles - All 9 versions
[CITATION] Variation and trends in incidence of childhood diabetes in Europe
JL Santiago, A Martínez, H de La Calle, M Fernández- … - Human immunology, 2005 - Elsevier Several polymorphisms in regions where Th1 cytokines (IL12B and IFNG genes) are located
were analyzed in 303 Spanish subjects with type 1 diabetes and compared with a control cohort
(n = 548). Both groups comprised residents of the Madrid area. The haplotype ... Cited by 2 - Related articles - All 4 versions
