- ►diabetesjournals.org M Matsumoto, W Ogawa, K Teshigawara, H Inoue, K … - Diabetes, 2002 - Am Diabetes Assoc The mechanism by which insulin induces the expression of the sterol regulatory element binding
protein 1c (SREBP-1c) and glucokinase genes was investigated in cultured rat hepatocytes.
Overexpression of an NH 2 -terminal fragment of IRS-1 that contains the pleckstrin ... Cited by 63 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] M Fleischmann, PB Iynedjian - Biochemical Journal, 2000 - pubmedcentral.nih.gov Insulin stimulates the transcription of the sterol regulatory- element binding protein (SREBP)
1\ADD1 gene in liver. Hepa- tocytes in primary culture were used to delineate the insulin signalling
pathway for induction of SREBP1 gene expression. The inhibitors of phosphoinositide 3- ... Cited by 107 - Related articles - BL Direct - All 7 versions
- ►nih.gov K Miyake, W Ogawa, M Matsumoto, T … - Journal of Clinical …, 2002 - Am Soc Clin Investig The physiological relevance of phosphoinositide 3-kinase (PI 3-K) signaling in the liver to fuel
homeostasis was investigated. Systemic infusion of an adenovirus encoding a dominant negative
mutant of PI 3-K (Δp85) resulted in liver-specific expression of this protein and in ... Cited by 70 - Related articles - BL Direct - All 10 versions
- ►nih.gov [PDF] PB Iynedjian, RA Roth, M Fleischmann, A … - Biochemical …, 2000 - pubmedcentral.nih.gov Inhibitors of signalling pathways were used to dissect the mechanism of insulin action on expression
of the gene encoding glucokinase in cultured rat hepatocytes. Wortmannin and LY 294002 completely
prevented the insulin-induced increase in glucokinase mRNA seen in unhibited cells, ... Cited by 32 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org I Guillet-Deniau, V Mieulet, S Le Lay, Y Achouri, D … - Diabetes, 2002 - Am Diabetes Assoc Sterol regulatory element binding protein-1c (SREBP-1c) is a transcription factor that mediates
insulin effects on hepatic gene expression. It is itself transcriptionally stimulated by insulin in
hepatocytes. Here we show that SREBP-1c mRNA is expressed in adult rat skeletal ... Cited by 62 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] D Azzout-Marniche, D Becard, C Guichard, M … - Biochemical …, 2000 - pubmedcentral.nih.gov The transcription factor sterol regulatory-element-binding protein-1c (SREBP-1c) plays a major
role in the effect of insulin on the transcription of hepatic genes such as glucokinase and fatty
acid synthase. We show here in cultured rat hepatocytes that insulin, through activation of ... Cited by 148 - Related articles - BL Direct - All 6 versions
- ►nih.gov M Matsumoto, W Ogawa, K Akimoto, H … - Journal of Clinical …, 2003 - Am Soc Clin Investig PKCλ is implicated as a downstream effector of PI3K in insulin action. We show here that mice
that lack PKCλ specifically in the liver (L-λKO mice), produced with the use of the Cre-loxP
system, exhibit increased insulin sensitivity as well as a decreased triglyceride content ... Cited by 75 - Related articles - BL Direct - All 11 versions
PG Ribaux, PB Iynedjian - Biochemical Journal, 2003 - bj.portlandpress.com Previous work showed that acute stimulation of a conditionally active protein kinase B (PKB or
cAKT) was sufficient to elicit insulin-like induction of GCK (glucokinase) and SREBP1 (sterol
regulatory element-binding protein 1) in hepatocytes [Iynedjian, Roth, Fleischmann and ... Cited by 35 - Related articles - View as HTML - BL Direct - All 8 versions
- ►jbc.org D Wang, HS Sul - Journal of Biological Chemistry, 1998 - ASBMB Fatty acid synthase (FAS) is a critical enzyme in de novo lipogenesis. It catalyzes the seven steps
in the conversion of malonyl-CoA and acetyl-CoA to palmitate. We have shown that the rate of
FAS transcription is induced dramatically when fasted animals are refed with a high ... Cited by 99 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org D Bécard, I Hainault, D Azzout-Marniche, L Bertry- … - Diabetes, 2001 - Am Diabetes Assoc In vitro, the transcription factor sterol regulatory element binding protein-1c (SREBP-1c) mimics
the positive effects of insulin on hepatic genes involved in glucose utilization, such as glucokinase
(GK) and enzymes of the lipogenic pathway, suggesting that it is a key factor in the control ... Cited by 91 - Related articles - BL Direct - All 4 versions
