- ►diabetesjournals.org L Brennan, A Shine, C Hewage, JPG … - Diabetes, 2002 - Am Diabetes Assoc Early experiments indicated that islet β-cells substantially metabolized
l-alanine but that insulin secretion was largely unaffected by the amino acid.
It was subsequently demonstrated using more intricate studies that ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►unige.ch [PDF] C Broca, L Brennan, P Petit, P Newsholme, P … - FEBS letters, 2003 - Elsevier In pancreatic β-cells, glutamate has been proposed to mediate insulin secretion
as a glucose-derived factor, although it is also considered for its sole
catabolic function. Hence, changes in cellular glutamate levels are a ... Cited by 22 - Related articles - All 6 versions
L Brennan, M Corless, C Hewage, JPG … - Diabetologia, 2003 - Springer Aims/hypothesis. Pancreatic islet cells and clonal beta- cell lines can
metabolise L-glutamine at high rates. The pathway of L-glutamine metabolism has
tradi- tionally been described as L-glutamine→L-gluta- ... Cited by 22 - Related articles - BL Direct - All 3 versions
- ►unige.ch [PDF] M Høy, P Maechler, AM Efanov, CB Wollheim … - FEBS letters, 2002 - Elsevier Glutamate has been implicated as an intracellular messenger in the regulation of
insulin secretion in response to glucose. Here we demonstrate by measurements of
cell capacitance in rat pancreatic β-cells that glutamate (1 mM) enhanced ... Cited by 32 - Related articles - All 8 versions
MJ Dunne, DI Yule, DV Gallacher, OH … - Biochim Biophys Acta, 1990 - grande.nal.usda.gov Record Detail. Return to previous page, Save: Title: Effects of alanine on
insulin-secreting cells: patch-clamp and single cell intracellular Ca2+ measurements. ... Cited by 18 - Related articles - Cached - All 3 versions
- ►endocrinology-journals.org [PDF] G Dixon, J Nolan, N McClenaghan, PR Flatt, … - Journal of Endocrinology, 2003 - Soc Endocrinology Evidence has been published that -alanine may, under appropriate conditions,
promote insulin secretion in nor- mal rodent islets and various beta cell lines.
Previous results utilising the clonal beta-cell line BRIN-BD11, demon- ... Cited by 15 - Related articles - BL Direct - All 5 versions
A Danielsson, B Hellman, LA Idahl - Horm Metab Res, 1970 - thieme-connect.com The possibility that conformational changes of glutamate dehydrogenase represent
a way of controlling insulin release was evaluated by measuring the levels of
?-ketoglutarate and glutamate in ?-cells in different states of functional ... Cited by 24 - Related articles - All 2 versions
A Sener, WJ Malaisse - BBA-General Subjects, 2002 - Elsevier Available information on the fate and insulinotropic action of -alanine in
isolated pancreatic islets is restricted to data collected in obese
hyperglycemic mice. Recent data, however, collected mostly in tumoral islet ... Cited by 11 - Related articles - All 5 versions
G Bertrand, N Ishiyama, M Nenquin, MA … - Journal of Biological Chemistry, 2002 - ASBMB Glucose increases insulin secretion by raising cytoplasmic Ca 2+ ([Ca 2+ ] i )
in β-cells (triggering pathway) and augmenting the efficacy of Ca 2+ on
exocytosis (amplifying pathway). It has been suggested that glutamate ... Cited by 68 - Related articles - BL Direct - All 5 versions
NH McClenaghan, CR Barnett, PR Flatt - Biochemical and Biophysical Research …, 1998 - Elsevier The involvement of Na + in insulin-secretory responses to metabolizable and
nonmetabolizable amino acids known to be cotransported with Na + , were examined
using islet-derived BRIN-BD11 cells. At stimulatory (16.7 mM) glucose, 10 ... Cited by 14 - Related articles - BL Direct - All 7 versions
