- ►diabetesjournals.org DR Laybutt, GC Weir, H Kaneto, J Lebet, RD … - Diabetes, 2002 - Am Diabetes Assoc To test the hypothesis that c-Myc plays an important role in β-cell growth and
differentiation, we generated transgenic mice overexpressing c-Myc in β-cells
under control of the rat insulin II promoter. F 1 transgenic mice from two ... Cited by 70 - Related articles - BL Direct - All 5 versions
H Kaneto, A Sharma, K Suzuma, DR Laybutt, … - Journal of Biological Chemistry, 2002 - ASBMB Insulin biosynthesis and secretion are critical for pancreatic -cell function,
but both are impaired under diabetic conditions. We have found that
hyperglycemia induces the expression of the basic helix-loop-helix ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►jbc.org JC Jonas, DR Laybutt, GM Steil, N Trivedi, … - Journal of Biological Chemistry, 2001 - ASBMB Glucose-induced insulin secretion from hyperglycemic 90% pancreatectomized rats
is markedly impaired, possibly because of loss of cell differentiation.
Association of these changes with cell hypertrophy, increased mRNA levels ... Cited by 64 - Related articles - BL Direct - All 5 versions
- ►lsuhsc.edu [PDF] M Van de Casteele, BA Kefas, Y Cai, H … - Biochemical and Biophysical Research …, 2003 - Elsevier Prolonged culture in low-glucose concentrations ( 5 mM) induces apoptosis in
pancreatic β-cells by a poorly defined mechanism. We now show that, in both
purified rat β-cells and isolated rat islets, culture in the presence of 3 ... Cited by 40 - Related articles - All 11 versions
DR Laybutt, M Glandt, G Xu, YB Ahn, N … - Journal of Biological Chemistry, 2003 - ASBMB We have proposed that hyperglycemia-induced dedifferentiation of -cells is a
critical factor for the loss of insulin secretory function in diabetes. Here we
examined the effects of the duration of hyperglycemia on gene expression in ... Cited by 69 - Related articles - BL Direct - All 4 versions
S Pelengaris, M Khan, GI Evan - Cell, 2002 - Elsevier To explore the role of c-Myc in carcinogenesis, we have developed a reversible
transgenic model of pancreatic β cell oncogenesis using a switchable form of
the c-Myc protein. Activation of c-Myc in adult, mature β cells induces ... Cited by 325 - Related articles - All 13 versions
- ►aacrjournals.org ER Lawlor, L Soucek, L Brown-Swigart, K … - Cancer research, 2006 - AACR The pleiotropic effects of Myc function are thought to arise through its action
as a transcription factor, positively or negatively regulating target effector
genes. Induction of gene targets by Myc requires its dimerization with its ... Cited by 25 - Related articles - BL Direct - All 5 versions
H Elouil, AK Cardozo, DL Eizirik, JC Henquin … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Hyperglycaemia and the pro- inflammatory cytokine
IL-1β induce similar alterations of beta cell gene expression, including
up-regulation of c-Myc and haeme-oxygenase 1. These effects of ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►nih.gov JA Kushner, MA Ciemerych, E Sicinska, LM … - Molecular and Cellular Biology, 2005 - Am Soc Microbiol Regulation of adult ß-cell mass in pancreatic islets is essential to preserve
sufficient insulin secretion in order to appropriately regulate glucose
homeostasis. In many tissues mitogens influence development by stimulating ... Cited by 113 - Related articles - All 7 versions
JC Jonas, A Sharma, W Hasenkamp, H Ilkova, … - Journal of Biological Chemistry, 1999 - ASBMB Differentiated pancreatic β cells are unique in their ability to secrete
insulin in response to a rise in plasma glucose. We have proposed that the
unique constellation of genes they express may be lost in diabetes due to ... Cited by 272 - Related articles - BL Direct - All 4 versions
