- ►diabetesjournals.org M Lipsett, DT Finegood - Diabetes, 2002 - Am Diabetes Assoc Over the past few decades, we have come to appreciate that the β-cell mass is dynamic, with
a significant capacity for adaptation to changes in insulin demand (1). Increases in β-cell mass
may occur through increased β-cell replication, increased β-cell size, decreased β-cell ... Cited by 85 - Related articles - BL Direct - All 5 versions
M Paris, C Bernard-Kargar, MF Berthault, L Bouwens, A … - Endocrinology, 2003 - Endocrine Soc We investigated the specific and associated effects of insulin and glucose on ß-cell growth and
function in adult rats. By combining simultaneous infusion either of glucose and/or insulin or
glucose and diazoxide, three groups of rats were constituted: hyperglycemic- ... Cited by 63 - Related articles - BL Direct - All 6 versions
- ►endojournals.org Y Guz, I Nasir, G Teitelman - Endocrinology, 2001 - Endocrine Soc We previously reported that new ß cells differentiated in pancreatic islets of mice in which diabetes
was produced by injection of a high dose of the ß cell toxin streptozotocin (SZ), which produces
hyperglycemia due to rapid and massive ß cell death. After SZ-mediated elimination of ... Cited by 186 - Related articles - BL Direct - All 5 versions
I Rooman, J Lardon, L Bouwens - Diabetes, 2002 - Am Diabetes Assoc It is still unclear which factors regulate pancreatic regeneration and β-cell neogenesis and which
precursor cells are involved. We evaluated the role of intravenously infused gastrin in regenerating
pancreas of duct-ligated rats. The ligation of exocrine ducts draining the splenic half of the ... Cited by 103 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] E Montanya, V Nacher, M Biarnes, J Soler - Diabetes, 2000 - Am Diabetes Assoc We determined the -cell replicative rate, -cell apo- ptosis, cross-sectional -cell area, and pancreatic
-cell mass throughout the entire postweaning lifespan (months 1, 3, 7, 10, 15, and 20) of Lewis
rats. -Cell replication was progressively reduced in the initial months of life but remained ... Cited by 84 - Related articles - BL Direct - All 4 versions
L Scaglia, FE Smith, S Bonner-Weir - Endocrinology, 1995 - Endocrine Soc Page 1. 0013-7227/95/$03.00/O Endocrinology Copyright 0 1995 by The Endocrine
Society Vol. 136, No. 12 Printed in USA Apoptosis Contributes to the Involution of p
Cell Mass in the Post Pax-turn Rat Pancreas* LUISA SCAGLIAT ... Cited by 117 - Related articles - BL Direct - All 3 versions
- ►fasebj.org C BERNARD, M BERTHAULT, C SAULNIER, A … - The FASEB Journal, 1999 - FASEB We have investigated in adult rats made mildly diabetic by a low dose of streptozotocin (35
mg/kg; STZ rats) and in nondiabetic rats (ND rats) the mechanisms leading to adaptive changes
in the ß cell mass, during glucose infusion and several days after stopping infusion. As ... Cited by 83 - Related articles - BL Direct - All 6 versions
- ►endojournals.org A Fernandes, LC King, Y Guz, R Stein, CVE Wright, G … - Endocrinology, 1997 - Endocrine Soc The ability of the adult pancreas to generate new insulin (ß) cells has been controversial because
of difficulties in unequivocally identifying the precursor population. We recently determined that
ß cells were generated during development from precursors that expressed the ... Cited by 172 - Related articles - BL Direct - All 4 versions
- ►massgeneral.org [PDF] S Kodama, W Kuhtreiber, S Fujimura, EA Dale, DL … - Science, 2003 - sciencemag.org Nonobese diabetic (NOD) mice are a model for type 1 diabetes in humans. Treatment of NOD
mice with end-stage disease by injection of donor splenocytes and complete Freund's adjuvant
eliminates autoimmunity and permanently restores normoglycemia. The return of ... Cited by 247 - Related articles - All 12 versions
L Bouwens - Microscopy research and technique, 1998 - interscience.wiley.com The pancreas is composed of at least three types of differentiated tissue: the hormone-containing
cells in islets (4 different cell types), the exocrine zymogen-containing acini, and the centroacinar
cells, ductules and ducts (ductal tree). All of these cells appear to have a common origin ... Cited by 116 - Related articles - BL Direct - All 4 versions
