- ►diabetesjournals.org K Saeki, M Zhu, A Kubosaki, J Xie, MS Lan, AL Notkins - Diabetes, 2002 - Am Diabetes Assoc IA-2 is a major autoantigen in type 1 diabetes. Autoantibodies to IA-2 appear years before the
development of clinical disease and are being widely used as predictive markers to identify individuals
at risk for developing type 1 diabetes. IA-2 is an enzymatically inactive member of the ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►nih.gov S Harashima, A Clark, MR Christie, AL … - Proceedings of the …, 2005 - National Acad Sciences IA-2 is an enzymatically inactive member of the transmembrane protein tyrosine phosphate family
located in dense core secretory vesicles and a major autoantigen in type 1 diabetes. Recent
studies showed that targeted disruption of the IA-2 gene in mice resulted in impairment of ... Cited by 27 - Related articles - All 9 versions
- ►rupress.org M Trajkovski, H Mziaut, A Altkruger, J Ouwendijk, … - Journal of Cell …, 2004 - jcb.rupress.org Islet cell autoantigen 512 (ICA512)/IA-2 is a receptor tyrosine phosphatase-like protein associated
with the insulin secretory granules (SGs) of pancreatic ß-cells. Here, we show that exocytosis
of SGs and insertion of ICA512 in the plasma membrane promotes the Ca 2+ -dependent ... Cited by 35 - Related articles - All 11 versions
A Kubosaki, S Gross, J Miura, K Saeki, M Zhu, S … - Diabetes, 2004 - Am Diabetes Assoc Insulinoma-associated protein (IA)-2β, also known as phogrin, is an enzymatically inactive member
of the transmembrane protein tyrosine phosphatase family and is located in dense-core secretory
vesicles. In patients with type 1 diabetes, autoantibodies to IA-2β appear years before the ... Cited by 26 - Related articles - BL Direct - All 8 versions
S Gross, C Blanchetot, J Schepens, S Albet, R … - Journal of Biological …, 2002 - ASBMB Most receptor-type protein-tyrosine phosphatases (RPTPs) contain two tandem PTP
domains. For some RPTPs the enzymatically inactive membrane-distal phosphatase domains
(D2) were found to bind enzymatically active membrane proximal PTP (D1) domains, and ... Cited by 21 - Related articles - BL Direct - All 5 versions
G Magistrelli, S Toma, A Isacchi - Biochemical and Biophysical Research …, 1996 - Elsevier The PTP35/IA-2 protein shows high homology to protein tyrosine phosphatases (PTPases) but
harbours a few changes in invariant PTPase residues. Accordingly, PTP35/IA-2 has been reported
to lack catalytic activityin vitro,and itsin vivobiological function remains to be determined. ... Cited by 47 - Related articles - BL Direct - All 5 versions
T Ort, E Maksimova, R Dirkx, AM Kachinsky, S … - European Journal of Cell …, 2000 - Elsevier Islet cell autoantigen (ICA) 512 of type I diabetes is a receptor tyrosine phosphatase-like protein
associated with the secretory granules of neurons and endocrine cells including insulin-secreting
β-cells of the pancreas. Here we show that in a yeast two-hybrid assay its cytoplasmic ... Cited by 53 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] M Solimena, R Dirkx Jr, JM Hermel, S Pleasic- … - The EMBO …, 1996 - pubmedcentral.nih.gov The EMBO Journal vol.15 no.9 pp.2102-2114, 1996 ... ICA 512, an autoantigen of type I
diabetes, is an ... Michele Solimena1, Ronald Dirkx Jr, Jean-Michel Hermel, Susan
Pleasic-Williams2, Jeffrey A.Shapiro2, Laurent Caron3 and Daniel U.Rabin2 Cited by 170 - Related articles - BL Direct - All 5 versions
T Ort, S Voronov, J Guo, K Zawalich, SC … - The EMBO …, 2001 - pubmedcentral.nih.gov Islet cell autoantigen (ICA) 512 is a receptor-tyrosine phosphatase-like protein associated with
the secretory granules of neuroendocrine cells, including pancreatic β-cells. Binding of its cytoplasmic
tail to β2-syntrophin suggests that ICA512 connects secretory granules to the utrophin ... Cited by 75 - Related articles - BL Direct - All 3 versions
JM Hermel, R Dirkx, M Solimena - European Journal of …, 1999 - ingentaconnect.com The autoantigen of type I diabetes ICA512 is a receptor tyrosine phosphatase-like protein enriched
in the secretory granule membranes of neurons and peptide secreting endocrine cells. While
the function of ICA512 remains unknown, it is thought to link regulated neuropeptide and ... Cited by 40 - Related articles - BL Direct - All 5 versions
