- ►diabetesjournals.org R Sreekumar, P Halvatsiotis, JC Schimke, KS … - Diabetes, 2002 - Am Diabetes Assoc Type 2 diabetes is characterized by muscle insulin resistance. Nondiabetic
first-degree relatives of type 2 diabetic patients have also been reported to
have insulin resistance. A polygenic basis for pathogenesis of type 2 ... Cited by 135 - Related articles - BL Direct - All 6 versions
X Yang, R Pratley, S Tokraks, C Bogardus, P … - Diabetologia, 2002 - Springer Aims/hypothesis. We carried out global transcript profiling to identify
differentially expressed skeletal muscle genes in insulin resistance, a major
risk fac- tor for Type II (non-insulin-dependent) diabetes mellitus. This ... Cited by 55 - Related articles - BL Direct - All 3 versions
- ►nih.gov VK Yechoor, ME Patti, R Saccone, CR Kahn - Proceedings of the National Academy of Sciences of …, 2002 - National Acad Sciences Metabolic abnormalities underlying diabetes are primarily the result of the lack
of adequate insulin action and the associated changes in protein phosphorylation
and gene expression. To define the full set of alterations in gene ... Cited by 96 - Related articles - BL Direct - All 10 versions
- ►nih.gov CS Stump, KR Short, ML Bigelow, JM Schimke … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences Mitochondria are the primary site of skeletal muscle fuel metabolism and ATP
production. Although insulin is a major regulator of fuel metabolism, its effect
on mitochondrial ATP production is not known. Here we report increases in ... Cited by 133 - Related articles - BL Direct - All 10 versions
- ►pnas.org ME Patti, AJ Butte, S Crunkhorn, K Cusi, R … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Type 2 diabetes mellitus (DM) is characterized by insulin resistance and
pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable
abnormality is insulin resistance in skeletal muscle. Impaired ... Cited by 663 - Related articles - BL Direct - All 15 versions
- ►shouxi.net YW Asmann, CS Stump, KR Short, JM Coenen- … - Diabetes, 2006 - Am Diabetes Assoc We investigated whether previously reported muscle mitochondrial dysfunction and
altered gene transcript levels in type 2 diabetes might be secondary to abnormal
blood glucose and insulin levels rather than an intrinsic defect of type 2 ... Cited by 49 - Related articles - BL Direct - All 5 versions
K Højlund, K Wrzesinski, PM Larsen, SJ Fey, … - Journal of Biological Chemistry, 2003 - ASBMB Insulin resistance in skeletal muscle is a hallmark feature of type 2 diabetes.
An increasing number of enzymes and metabolic pathways have been implicated in
the development of insulin resistance. However, the primary cellular cause ... Cited by 92 - Related articles - BL Direct - All 5 versions
KF Petersen, S Dufour, GI Shulman - PLoS Medicine, 2005 - medicine.plosjournals.org Rates of insulin-stimulated muscle mitochondrial ATP synthase flux and
insulin-stimulated increases in concentrations of intramyocellular inorganic
phosphate (P i ) were assessed by 31 P magnetic resonance spectroscopy ... Cited by 101 - Related articles - Cached - BL Direct - All 12 versions
- ►shouxi.net VB Ritov, EV Menshikova, J He, RE Ferrell, … - Diabetes, 2005 - Am Diabetes Assoc The current study addresses a novel hypothesis of subcellular distribution of
mitochondrial dysfunction in skeletal muscle in type 2 diabetes. Vastus
lateralis muscle was obtained by percutaneous biopsy from 11 volunteers ... Cited by 194 - Related articles - All 6 versions
DE Kelley, J He, EV Menshikova, VB Ritov - Diabetes, 2002 - Am Diabetes Assoc Skeletal muscle is strongly dependent on oxidative phosphorylation for energy
production. Because the insulin resistance of skeletal muscle in type 2 diabetes
and obesity entails dysregulation of the oxidation of both carbohydrate and ... Cited by 531 - Related articles - BL Direct - All 4 versions
