T Rosenzweig, L Braiman, A Bak, A Alt, T Kuroki, SR … - Diabetes, 2002 - Am Diabetes Assoc Tumor necrosis factor-α (TNF-α) is a multifunctional cytokine that interferes with insulin
signaling, but the molecular mechanisms of this effect are unclear. Because certain protein kinase
C (PKC) isoforms are activated by insulin, we examined the role of PKC in TNF-α ... Cited by 36 - Related articles - BL Direct - All 5 versions
T Rosenzweig, L Braiman, A Bak, A Alt, T Kuroki, SR … - Diabetes, 2002 - Am Diabetes Assoc Tumor necrosis factor- (TNF- ) is a multifunctional cytokine that interferes with insulin
signaling, but the molecular mechanisms of this effect are unclear. Be- cause certain protein
kinase C (PKC) isoforms are activated by insulin, we examined the role of PKC in TNF- ... Cited by 9 - Related articles
- ►endojournals.org L Braiman, A Alt, T Kuroki, M Ohba, A Bak, T … - Molecular …, 2001 - Endocrine Soc Certain protein kinase C (PKC) isoforms, in particular PKCs ßII, , and , are activated by insulin
stimulation. In primary cultures of skeletal muscle, PKCs ßII and , but not PKC , are activated
via a phosphatidylinositol 3-kinase (PI3K)-dependent pathway. The purpose of this study ... Cited by 38 - Related articles - BL Direct - All 7 versions
T Rosenzweig, S Aga-Mizrachi, A Bak, SR Sampson - Cellular signalling, 2004 - Elsevier Insulin stimulation of skeletal muscle results in rapid activation of protein kinase Cδ (PKCδ), which
is associated with its tyrosine phosphorylation and physical association with insulin receptor
(IR). The mechanisms underlying tyrosine phosphorylation of PKCδ have not been ... Cited by 21 - Related articles - All 3 versions
- ►endojournals.org L Braiman, A Alt, T Kuroki, M Ohba, A Bak, T … - Molecular …, 1999 - Endocrine Soc Insulin activates certain protein kinase C (PKC) isoforms that are involved in insulin-induced
glucose transport. In this study, we investigated the possibility that activation of PKC by insulin
participates in the mediation of insulin effects on glucose transport in skeletal muscle. ... Cited by 67 - Related articles - BL Direct - All 6 versions
- ►nih.gov SR Sampson, DR Cooper - Molecular genetics and metabolism, 2006 - Elsevier Recent studies implicate specific PKC isoforms in the insulin-signaling cascade. Insulin activates
PKCs α, βII, δ and ζ in several cell types. In addition, as will be documented in this review, certain
members of the PKC family may also be activated and act upstream of PI3 and MAP ... Cited by 24 - Related articles - All 4 versions
M Cipok, S Aga-Mizrachi, A Bak, T Feurstein, R … - … and Biophysical Research …, 2006 - Elsevier Certain PKC isoforms are stimulated by insulin and interact with IR as well as with IRS, but it
is still not clear if specific PKC isoforms regulate IR signaling directly or through IRS-1. PKCα
may regulate IRS activity in response to insulin. We investigated the possibility that PKCα ... Cited by 7 - Related articles - All 5 versions
L Braiman, L Shefft-Friedman, A Bak, T … - DIABETES-NEW …, 1999 - Am Diabetes Assoc Several reports indicate that protein kinase C (PKC) plays a role in insulin-induced glucose transport
in cer- tain cells. The precise effects of insulin on specific PKC isoforms are as yet unknown.
Utilizing primary cultures of rat skeletal muscle, we investigated the possibility that insulin ... Cited by 81 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org I Nieto-Vazquez, S Fernández-Veledo, C de Alvaro, … - Diabetes, 2007 - Am Diabetes Assoc Protein–tyrosine phosphatase (PTP)1B is a negative regulator of insulin signaling and a therapeutic
target for type 2 diabetes. In this study, we have assessed the role of PTP1B in the insulin sensitivity
of skeletal muscle under physiological and insulin-resistant conditions. Immortalized ... Cited by 21 - Related articles - BL Direct - All 6 versions
M Horovitz-Fried, DR Cooper, NA Patel, M Cipok, C … - Cellular signalling, 2006 - Elsevier Recent studies in our laboratories have shown that Protein Kinase C delta (PKCδ) is essential
for insulin-induced glucose transport in skeletal muscle, and that insulin rapidly stimulates PKCδ
activity skeletal muscle. The purpose of this study was to examine mechanisms of ... Cited by 6 - Related articles - All 4 versions
