L Hornum, J Rømer, H Markholst - Diabetes, 2002 - Am Diabetes Assoc Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes
resembling human type 1 diabetes. They also exhibit lifelong T-cell lymphopenia.
Functional and genetic data support the hypothesis that the gene ... Cited by 90 - Related articles - BL Direct - All 4 versions
- ►171.66.122.45 AJ MacMurray, DH Moralejo, AE Kwitek, EA … - Genome research, 2002 - genome.cshlp.org The BB (BioBreeding) rat is one of the best models of spontaneous autoimmune
diabetes and is used to study non-MHC loci contributing to Type 1 diabetes. Type
1 diabetes in the diabetes-prone BB (BBDP) rat is polygenic, dependent upon ... Cited by 112 - Related articles - BL Direct - All 12 versions
- ►nih.gov M Pandarpurkar, L Wilson-Fritch, S Corvera, H … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Apoptosis is a regulated cell death program controlled by extrinsic and
intrinsic signaling pathways. The intrinsic pathway involves stress signals that
activate pro-apoptotic members of the Bcl-2 family, inducing ... Cited by 48 - Related articles - BL Direct - All 11 versions
- ►molbiolcell.org T Sandal, L Aumo, L Hedin, BT Gjertsen, SO … - Molecular biology of the cell, 2003 - Am Soc Cell Biol Protein phosphatase-directed toxins such as okadaic acid (OA) are general
apoptosis inducers. We show that a protein (inhibitor of radiation- and
OA-induced apoptosis, Irod/Ian5), belonging to the family of ... Cited by 38 - Related articles - BL Direct - All 4 versions
- ►nih.gov L Daheron, T Zenz, LD Siracusa, C Brenner, B … - Nucleic acids research, 2001 - Oxford Univ Press Using the representation difference analysis technique, we have identified a
novel gene, Ian4, which is preferentially expressed in hematopoietic precursor
32D cells transfected with wild-type versus mutant forms of the Bcr/Abl ... Cited by 34 - Related articles - BL Direct - All 7 versions
- ►physiology.org … , T Michalkiewicz, RA Ettinger, EA Rutledge, … - Physiological Genomics, 2004 - Am Physiological Soc A single point mutation in a novel immune-associated nucleotide gene 5 (Ian5)
coincides with severe T cell lymphopenia in BB rats. We used a transgenic rescue
approach in lymphopenic BB-derived congenic F344.lyp/lyp rats to determine ... Cited by 28 - Related articles - All 4 versions
T Zenz, A Roessner, A Thomas, S Fröhling, H … - Genes and immunity, 2004 - nature.com The family of immune associated nucleotide binding proteins (Ian) is a distinct
family of GTP-binding proteins conserved in plants, mice, rats and humans that
are associated with immune functions, suggesting involvement in conserved ... Cited by 22 - Related articles - BL Direct - All 4 versions
T Nitta, M Nasreen, T Seike, A Goji, I … - biology.plosjournals.org The soil nematodes Caenorhabditis briggsae and Caenorhabditis elegans diverged
from a common ancestor roughly 100 million years ago and yet are almost
indistinguishable by eye. They have the same chromosome number and genome ... Cited by 33 - Related articles - Cached - BL Direct - All 12 versions
O Stamm, J Krücken, HP Schmitt-Wrede, WPM … - Gene, 2002 - Elsevier Inducibility of the mouse gene imap38 in the spleen has been recently described
to correlate with resistance to Plasmodium chabaudi malaria. Here, we
characterize the human ortholog gene himap1. The HIMAP1 34 kDa protein is ... Cited by 25 - Related articles - All 5 versions
- ►jimmunol.org G Poirier, G Anderson, A Huvar, PC Wagaman, … - The Journal of Immunology, 1999 - Am Assoc Immnol Positive selection of thymocytes is a complex and crucial event in T cell
development that is characterized by cell death rescue, commitment toward the
helper or cytotoxic lineage, and functional maturation of thymocytes ... Cited by 40 - Related articles - BL Direct - All 3 versions
