- ►diabetesjournals.org N Lahlou, T Issad, Y Lebouc, JC Carel, L Camoin, M … - Diabetes, 2002 - Am Diabetes Assoc A part of serum Ob leptin, an adipocyte-secreted peptide, is bound to a soluble Ob receptor
(sObR). Immunoreactive sObR was measured in 125 lean or obese control subjects (group
1), 18 individuals with a mutation in the leptin gene impairing leptin secretion (group 2), ... Cited by 37 - Related articles - BL Direct - All 6 versions
- ►endojournals.org FMH van Dielen, C van't Veer, WA Buurman, … - Journal of Clinical …, 2002 - Endocrine Soc Furthermore, plasma levels of sLR and leptin were measured in 21 lean individuals and in 30
morbidly obese subjects before and 3, 6, and 12 months after gastric restrictive surgery.
Preoperatively, leptin concentrations significantly correlated with body mass index (r = ... Cited by 75 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org JL Chan, S Blüher, N Yiannakouris, MA Suchard, J … - Diabetes, 2002 - Am Diabetes Assoc Leptin is an adipocyte-secreted hormone important in energy homeostasis and diverse physiological
processes. A circulating soluble form of the leptin receptor [soluble leptin receptor (sOB-R)] is
the main leptin-binding protein and determinant of free leptin index (FLI), the presumed ... Cited by 108 - Related articles - BL Direct - All 7 versions
H Shimizu, K Shimomura, M Negishi, M Masunaga, Y … - Nutrition, 2002 - Elsevier Concentrations of the soluble leptin receptor (sOB-R) may be related to leptin resistance in
obesity. We measured sOB-R concentrations in serum in 103 non-diabetic Japanese men and
women. All subjects were grouped according to body mass index (BMI; in kg/m 2 ). Serum ... Cited by 36 - Related articles - BL Direct - All 9 versions
P Monteleone, M Fabrazzo, A Tortorella, A … - Molecular …, 2002 - ncbi.nlm.nih.gov Leptin is thought to modulate feeding behaviour, body weight and energy metabolism by acting
through specific cellular receptors. Derangements of leptin production have been repeatedly
reported in patients with anorexia nervosa (AN) or bulimia nervosa (BN), but no ... Cited by 37 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org [PDF] N Lahlou, K Clement, JC Carel, C Vaisse, C Lotton, Y … - Diabetes, 2000 - Am Diabetes Assoc Leptin resistance and obesity have been related to muta- tions of the leptin receptor gene in
rodents and, recently, in a consanguineous family. The latter mutation results in a receptor lacking
transmembrane and intracellular domains. Homozygous and heterozygous individuals ... Cited by 67 - Related articles - BL Direct - All 5 versions
A Lammert, W Kiess, A Bottner, A Glasow, J … - … and biophysical research …, 2001 - Elsevier In human blood leptin circulates both free and bound to high molecular weight proteins. Hypothesising
that these proteins may modulate ligand bioavailability and bioactivity of leptin, we investigated
their molecular nature. Therefore, leptin binding activity was partially purified from human ... Cited by 135 - Related articles - BL Direct - All 5 versions
- ►endojournals.org Z Wu, M Bidlingmaier, C Liu, EB De Souza, M … - Journal of Clinical …, 2002 - Endocrine Soc Panels of monoclonal antibodies (mAbs) were raised against recombinant human leptin and
the recombinant human soluble leptin receptor. Using these mAbs, we established a ligand-mediated
immunofunctional assay (LIFA) to quantify concentrations of the soluble leptin receptor, ... Cited by 18 - Related articles - BL Direct - All 5 versions
- ►endojournals.org J Kratzsch, A Lammert, A Bottner, B Seidel, G … - Journal of Clinical …, 2002 - Endocrine Soc Leptin is bound in human blood by a high affinity binding protein, which appears to be identical
with the soluble leptin receptor (sOB-R). Using a ligand-mediated immunofunctional assay for
the determination of serum sOB-R, we investigated its course during childhood, puberty, ... Cited by 85 - Related articles - BL Direct - All 5 versions
- ►endojournals.org M Maamra, M Bidlingmaier, MC Postel-Vinay, Z Wu, CJ … - Endocrinology, 2001 - Endocrine Soc The leptin receptor (ObR) exists in multiple isoforms. In rodents, a soluble isoform is generated
by alternative splicing; but in humans, there is no mRNA encoding soluble receptor (leptin binding
protein). We investigated the hypothesis that human leptin binding protein can be ... Cited by 72 - Related articles - BL Direct - All 2 versions
