SI Itani, NB Ruderman, F Schmieder, G Boden - Diabetes, 2002 - Am Diabetes Assoc The possibility that lipid-induced insulin resistance in human muscle is related
to alterations in diacylglycerol (DAG)/protein kinase C (PKC) signaling was
investigated in normal volunteers during euglycemic-hyperinsulinemic ... Cited by 522 - Related articles - BL Direct - All 4 versions
C Yu, Y Chen, GW Cline, D Zhang, H Zong, … - Journal of Biological Chemistry, 2002 - ASBMB Recent studies have demonstrated that fatty acids induce insulin resistance in
skeletal muscle by blocking insulin activation of insulin receptor substrate-1
(IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase). To examine ... Cited by 530 - Related articles - BL Direct - All 8 versions
- ►whitelabs.org [PDF] ME Griffin, MJ Marcucci, GW Cline, K Bell, N … - DIABETES-NEW YORK-, 1999 - Am Diabetes Assoc To examine the mechanism by which free fatty acids ( F FAs) induce insulin
resistance in vivo, awake chron- ically catheterized rats underwent a
hyperinsulinemic- euglycemic clamp with or without a 5-h preinfusion of ... Cited by 624 - Related articles - BL Direct - All 7 versions
C Schmitz-Peiffer, DL Craig, TJ Biden - Journal of Biological Chemistry, 1999 - ASBMB We have employed C2C12 myotubes to investigate lipid inhibition of
insulin-stimulated signal transduction and glucose metabolism. Cells were
preincubated for 18 h in the absence or presence of free fatty acids (FFAs) ... Cited by 287 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org G Boden, B Lebed, M Schatz, C Homko, S … - Diabetes, 2001 - Am Diabetes Assoc The reason for the 3- to 4-h delay between a rise in plasma free fatty acid
(FFA) levels and the development of insulin resistance remains unknown. In the
current study, we have tested the hypothesis that the delay may be caused ... Cited by 286 - Related articles - BL Direct - All 5 versions
- ►nih.gov A Dresner, D Laurent, M Marcucci, ME … - Journal of Clinical Investigation, 1999 - Am Soc Clin Investig To examine the mechanism by which free fatty acids (FFA) induce insulin
resistance in human skeletal muscle, glycogen, glucose-6-phosphate, and
intracellular glucose concentrations were measured using carbon-13 and ... Cited by 663 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org JM Adams, T Pratipanawatr, R Berria, E … - Diabetes, 2004 - Am Diabetes Assoc Increased intramyocellular lipid concentrations are thought to play a role in
insulin resistance, but the precise nature of the lipid species that produce
insulin resistance in human muscle are unknown. Ceramides, either generated ... Cited by 117 - Related articles - BL Direct - All 9 versions
M Krssak, K Falk Petersen, A Dresner, L … - Diabetologia, 1999 - Springer Skeletal muscle insulin resistance is a common fea- ture of obesity,
dyslipidaemia and arterial hyperten- sion, and it is an important predisposing
factor for Type II (non-insulin-dependent) diabetes mellitus and premature ... Cited by 556 - Related articles - BL Direct - All 6 versions
- ►nih.gov JK Kim, YJ Kim, JJ Fillmore, Y Chen, I Moore, … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Insulin resistance is a major factor in the pathogenesis of type 2 diabetes and
may involve fat-induced activation of a serine kinase cascade involving IKK-β.
To test this hypothesis, we first examined insulin action and signaling in ... Cited by 423 - Related articles - BL Direct - All 9 versions
- ►physiology.org BA Ellis, A Poynten, AJ Lowy, SM Furler, DJ … - American Journal of Physiology- Endocrinology And …, 2000 - Am Physiological Soc Long-chain acyl-CoAs (LCACoA) are an activated lipid species that are key
metabolites in lipid metabolism; they also have a role in the regulation of
other cellular processes. However, few studies have linked LCACoA content ... Cited by 149 - Related articles - BL Direct - All 4 versions
