- ►diabetesjournals.org E Marion, PJ Kaisaki, V Pouillon, C Gueydan, … - Diabetes, 2002 - Am Diabetes Assoc Genetic susceptibility to type 2 diabetes involves many genes, most of which are
still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of
insulin signaling and sensitivity in vivo and is thus a good candidate ... Cited by 57 - Related articles - BL Direct - All 6 versions
T Sasaoka, H Hori, T Wada, M Ishiki, T Haruta … - Diabetologia, 2001 - Springer Activation of the PI3-kinase is known to be extreme- ly important for exerting
various metabolic actions of insulin [1ą3].PI(3,4,5)P3 produced by the
activated PI3-kinase is thought to function as a key lipid second messenger ... Cited by 52 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org PJ Kaisaki, M Delépine, PY Woon, L Sebag- … - Diabetes, 2004 - Am Diabetes Assoc Type II SH2 domain–containing inositol 5-phosphatase (INPPL1, or SHIP2) plays
an important role in the control of insulin sensitivity. INPPL1 mutations
affecting gene function have been found in rat models of type 2 diabetes ... Cited by 23 - Related articles - BL Direct - All 5 versions
E Marion, PJ Kaisaki, V Pouillon, C Gueydan, … - DIABETES, 2002 - Am Diabetes Assoc Page 1. Rapid Publication The Gene INPPL1, Encoding the Lipid Phosphatase
SHIP2, Is a Candidate for Type 2 Diabetes In Rat and Man ... Related articles
- ►diabetesjournals.org H Hori, T Sasaoka, H Ishihara, T Wada, S … - Diabetes, 2002 - Am Diabetes Assoc SH-2-containing inositol 5′-phosphatase 2 (SHIP-2) is a physiologically
important lipid phosphatase that functions to hydrolyze phosphatidylinositol
(PI) 3-kinase product PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation ... Cited by 53 - Related articles - BL Direct - All 4 versions
- ►nih.gov T Wada, T Sasaoka, M Funaki, H Hori, S … - Molecular and Cellular Biology, 2001 - Am Soc Microbiol Phosphatidylinositol (PI) 3-kinase plays an important role in various metabolic
actions of insulin including glucose uptake and glycogen synthesis. Although PI
3-kinase primarily functions as a lipid kinase which preferentially ... Cited by 106 - Related articles - BL Direct - All 5 versions
- ►shouxi.net K Fukui, T Wada, S Kagawa, K Nagira, M … - Diabetes, 2005 - Am Diabetes Assoc We investigated the role of hepatic SH2-containing inositol 5′-phosphatase 2
(SHIP2) in glucose metabolism in mice. Adenoviral vectors encoding wild-type
SHIP2 (WT-SHIP2) and a dominant-negative SHIP2 (ΔIP-SHIP2) were injected ... Cited by 24 - Related articles - All 5 versions
MW Sleeman, KE Wortley, KMV Lai, LC Gowen, … - Nature medicine, 2005 - nature.com Genetic ablation of Inppl1, which encodes SHIP2 (SH2-domain containing inositol
5-phosphatase 2), was previously reported to induce severe insulin sensitivity,
leading to early postnatal death. In the previous study, the targeting ... Cited by 72 - Related articles - All 6 versions
- ►endojournals.org S Kagawa, T Sasaoka, S Yaguchi, H Ishihara, … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc TYPE 2 (NONINSULIN DEPENDENT) diabetes mellitus is a disorder characterized by
insulin resistance in the target tissue of insulin with insufficient insulin
secretion in pancreatic ß-cells (1). The molecular mechanisms underlying ... Cited by 10 - Related articles - All 4 versions
S Clément, U Krause, F Desmedt, JF Tanti, J … - Nature, 2001 - nature.com Insulin is the primary hormone involved in glucose homeostasis, and impairment
of insulin action and/or secretion has a critical role in the pathogenesis of
diabetes mellitus. Type-II SH2-domain-containing inositol 5-phosphatase, or ... Cited by 233 - Related articles - BL Direct - All 8 versions
