AA Dunn-Meynell, VH Routh, L Kang, L Gaspers, BE … - Diabetes, 2002 - Am Diabetes Assoc Specialized neurons utilize glucose as a signaling molecule to alter their firing rate.
Glucose-excited (GE) neurons increase and glucose-inhibited (GI) neurons reduce activity as
ambient glucose levels rise. Glucose-induced changes in the ATP-to-ADP ratio in GE ... Cited by 116 - Related articles - BL Direct - All 8 versions
L Kang, VH Routh, EV Kuzhikandathil, LD Gaspers, BE … - Diabetes, 2004 - Am Diabetes Assoc To evaluate potential mechanisms for neuronal glucosensing, fura-2 Ca 2+ imaging and
single-cell RT-PCR were carried out in dissociated ventromedial hypothalamic nucleus
(VMN) neurons. Glucose-excited (GE) neurons increased and glucose-inhibited (GI) ... Cited by 94 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org Z Song, BE Levin, JJ McArdle, N Bakhos, VH Routh - Diabetes, 2001 - Am Diabetes Assoc Glucosensing neurons in the ventromedial hypothalamic nucleus (VMN) were studied using
visually guided slice-patch recording techniques in brain slices from 14- to 21-day-old male
Sprague-Dawley rats. Whole-cell current-clamp recordings were made as extracellular ... Cited by 119 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org [PDF] RM Lynch, LS Tompkins, HL Brooks, AA Dunn-Meynell, … - Diabetes, 2000 - Am Diabetes Assoc The brain contains a subpopulation of glucosensing neu- rons that alter their firing rate in response
to elevated glucose concentrations. In pancreatic ß-cells, gluco- kinase (GK), the rate-limiting
enzyme in glycolysis, medi- ates glucose-induced insulin release by regulating intra- ... Cited by 112 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Wang, X Liu, ST Hentges, AA Dunn-Meynell, BE … - Diabetes, 2004 - Am Diabetes Assoc Glucosensing neurons in the hypothalamic arcuate nucleus (ARC) were studied using electrophysiological
and immunocytochemical techniques in neonatal male Sprague-Dawley rats. We identified
glucose-excited and -inhibited neurons, which increase and decrease, respectively, their ... Cited by 106 - Related articles - BL Direct - All 5 versions
XJ Yang, LM Kow, DW Pfaff, CV Mobbs - Diabetes, 2004 - Am Diabetes Assoc Neurons in the ventromedial hypothalamus mediate some counterregulatory responses to hypoglycemia
and 2-deoxyglucose, but the mechanisms that mediate these responses to glucose are
unclear. In the present study, ventromedial hypothalamus neurons were identified on the ... Cited by 44 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] XJ Yang, LM Kow, T Funabashi, CV Mobbs - Diabetes, 1999 - Am Diabetes Assoc Glucose-responsive neurons in the ventromedial hypo- thalamus (VMH) are stimulated when
glucose increases from 5 to 20 mmol/l and are thought to play an essential role in regulating
metabolism. The present studies exam- ined the role of glucose metabolism in the ... Cited by 186 - Related articles - BL Direct - All 5 versions
I Roncero, E Alvarez, P Vazquez, E … - Journal of …, 2000 - interscience.wiley.com Abstract: Recently, the description of glucokinase mRNA in certain neuroendocrine cells has
opened new ways to characterize this enzyme in the rat brain. In this study, we found glucokinase
mRNA and a similar RNA splicing pattern of the glucokinase gene product in rat ... Cited by 67 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org NM Sanders, AA Dunn-Meynell, BE Levin - Diabetes, 2004 - Am Diabetes Assoc Glucokinase (GK) is hypothesized to be the critical glucosensor of pancreatic β-cells and hypothalamic
glucosensing neurons. To understand the role of GK in glucoprivic counterregulatory
responses, we injected alloxan, a GK inhibitor and toxin, into the third ventricle (3v) to ... Cited by 36 - Related articles - BL Direct - All 4 versions
S Ritter, TT Dinh, Y Zhang - Brain research, 2000 - Elsevier Feeding and blood glucose responses to local injection of nanoliter volumes of 5-thio- -glucose
(5TG), a potent antimetabolic glucose analogue, were studied at 142 hindbrain and 61 hypothalamic
cannula sites. A site was considered positive if 5TG elicited at least 1.5 g more food intake ... Cited by 116 - Related articles - All 5 versions
