- ►diabetesjournals.org N Musi, MF Hirshman, J Nygren, M Svanfeldt, … - Diabetes, 2002 - Am Diabetes Assoc Metformin is an effective hypoglycemic drug that lowers blood glucose
concentrations by decreasing hepatic glucose production and increasing glucose
disposal in skeletal muscle; however, the molecular site of metformin ... Cited by 235 - Related articles - BL Direct - All 4 versions
SA Hawley, AE Gadalla, GS Olsen, DG Hardie - Diabetes, 2002 - Am Diabetes Assoc Metformin, a drug widely used to treat type 2 diabetes, was recently shown to
activate the AMP-activated protein kinase (AMPK) in intact cells and in vivo. In
this study we addressed the mechanism for this effect. In intact cells, ... Cited by 241 - Related articles - BL Direct - All 4 versions
- ►jbc.org LGD Fryer, A Parbu-Patel, D Carling - Journal of Biological Chemistry, 2002 - ASBMB AMP-activated protein kinase (AMPK) is activated within the cell in response to
multiple stresses that increase the intracellular AMP:ATP ratio. Here we show
that incubation of muscle cells with the thiazolidinedione, rosiglitazone, ... Cited by 494 - Related articles - BL Direct - All 4 versions
- ►nih.gov G Zhou, R Myers, Y Li, Y Chen, X Shen, J … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Metformin is a widely used drug for treatment of type 2 diabetes with no defined
cellular mechanism of action. Its glucose-lowering effect results from decreased
hepatic glucose production and increased glucose utilization. Metformin's ... Cited by 1110 - Related articles - BL Direct - All 7 versions
- ►nih.gov [PDF] MR Owen, E Doran, AP Halestrap - Biochemical Journal, 2000 - pubmedcentral.nih.gov Although metformin is widely used for the treatment of non- insulin-dependent
diabetes, its mode of action remains unclear. Here we provide evidence that its
primary site of action is through a direct inhibition of complex 1 of the ... Cited by 223 - Related articles - BL Direct - All 7 versions
MY El-Mir, V Nogueira, E Fontaine, N Avéret, … - Journal of Biological Chemistry, 2000 - ASBMB We report here a new mitochondrial regulation occurring only in intact cells. We
have investigated the effects of dimethylbiguanide on isolated rat hepatocytes,
permeabilized hepatocytes, and isolated liver mitochondria. Addition of ... Cited by 137 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org ES Buhl, N Jessen, R Pold, T Ledet, A … - Diabetes, 2002 - Am Diabetes Assoc The insulin resistance syndrome is characterized by several risk factors for
cardiovascular disease. Chronic chemical activation of AMP-activated protein
kinase by the adenosine analog 5-aminoimidazole-4-carboxamide-1-β -d- ... Cited by 93 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org R Bergeron, SF Previs, GW Cline, P Perret, … - Diabetes, 2001 - Am Diabetes Assoc Activation of AMP-activated protein kinase (AMPK) with
5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) increases glucose
transport in skeletal muscle via an insulin-independent pathway. To examine ... Cited by 134 - Related articles - BL Direct - All 4 versions
N Musi, N Fujii, MF Hirshman, I Ekberg, S … - Diabetes, 2001 - Am Diabetes Assoc Insulin-stimulated GLUT4 translocation is impaired in people with type 2
diabetes. In contrast, exercise results in a normal increase in GLUT4
translocation and glucose uptake in these patients. Several groups have ... Cited by 196 - Related articles - BL Direct - All 4 versions
M Zang, A Zuccollo, X Hou, D Nagata, K … - Journal of Biological Chemistry, 2004 - ASBMB The antidiabetic drug metformin stimulates AMP-activated protein kinase (AMPK)
activity in the liver and in skeletal muscle. To better understand the role of
AMPK in the regulation of hepatic lipids, we studied the effect of ... Cited by 94 - Related articles - BL Direct - All 4 versions
