C Huang, R Somwar, N Patel, W Niu, D Török, … - Diabetes, 2002 - Am Diabetes Assoc Hyperglycemia and hyperinsulinemia are cardinal features of acquired insulin
resistance. In adipose cell cultures, high glucose and insulin cause insulin
resistance of glucose uptake, but because of altered GLUT4 expression and ... Cited by 72 - Related articles - BL Direct - All 5 versions
- ►jbc.org D Li, VK Randhawa, N Patel, M Hayashi, A … - Journal of Biological Chemistry, 2001 - ASBMB The intracellular traffic of the glucose transporter 4 (GLUT4) in muscle cells
remains largely unexplored. Here we make use of L6 myoblasts stably expressing
GLUT4 with an exofacially directed Myc-tag (GLUT4myc) to determine the ... Cited by 75 - Related articles - BL Direct - All 3 versions
Q Wang, Z Khayat, K Kishi, Y Ebina, A Klip - FEBS letters, 1998 - Elsevier We report a rapid and sensitive colorimetric approach to quantitate the amount
of glucose transporters exposed at the surface of intact cells, using L6 muscle
cells expressing GLUT4 containing an exofacial myc epitope. Unstimulated ... Cited by 107 - Related articles - All 6 versions
LJ Foster, D Li, VK Randhawa, A Klip - Journal of Biological Chemistry, 2001 - ASBMB Insulin enhances plasmalemmal-directed traffic of glucose transporter-4 (GLUT4),
but it is unknown whether insulin regulates GLUT4 traffic through endosomal
compartments. In L6 myoblasts expressing Myc-tagged GLUT4, insulin markedly ... Cited by 67 - Related articles - BL Direct - All 3 versions
- ►physiology.org A Ueyama, KL Yaworsky, Q Wang, Y Ebina, A … - American Journal of Physiology- Endocrinology And …, 1999 - Am Physiological Soc Insulin stimulates glucose uptake into muscle and fat cells via recruitment of
the glucose transporter 4 (GLUT-4) from intracellular store(s) to the cell
surface. Robust stimulation of glucose uptake by insulin coincides with the ... Cited by 55 - Related articles - All 3 versions
- ►diabetesjournals.org D Konrad, PJ Bilan, Z Nawaz, G Sweeney, W … - Diabetes, 2002 - Am Diabetes Assoc There is a need to understand whether the amount of GLUT4 at the cell surface
determines the extent of glucose uptake in response to insulin. Thus, we created
a heterozygous mouse expressing modest levels of myc-tagged GLUT4 ... Cited by 47 - Related articles - BL Direct - All 6 versions
A Rudich, D Konrad, D Török, R Ben-Romano, … - Diabetologia, 2003 - Springer Aims/hypothesis. Insulin-dependent glucose influx in skeletal muscle and
adipocytes is believed to rely largely on GLUT4, but this has not been confirmed
di- rectly. We assessed the relative functional contribution of GLUT4 in ... Cited by 56 - Related articles - BL Direct - All 3 versions
- ►nih.gov P Tong, ZA Khayat, C Huang, N Patel, A … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Insulin stimulates glucose uptake by recruiting glucose transporter 4 (GLUT4)
from an intracellular compartment to the cell surface; this phenomenon is
defective in type 2 diabetes. Here we examine the involvement of actin ... Cited by 111 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] R Somwar, M Perreault, S Kapur, C Taha, G … - Diabetes, 2000 - Am Diabetes Assoc The stress-activated p38 mitogen-activated protein kinase (MAPK) was recently
shown to be activated by insulin in muscle and adipose cells in culture. Here,
we explore whether such stimulation is observed in rat skeletal muscle and ... Cited by 101 - Related articles - BL Direct - All 4 versions
G Sweeney, R Somwar, T Ramlal, A Volchuk, … - Journal of Biological Chemistry, 1999 - ASBMB The precise mechanisms underlying insulin-stimulated glucose transport still
require investigation. Here we assessed the effect of SB203580, an inhibitor of
the p38 MAP kinase family, on insulin-stimulated glucose transport in ... Cited by 254 - Related articles - All 4 versions
