- ►diabetesjournals.org RS Ahima, HR Patel, N Takahashi, Y Qi, SM Hileman, … - Diabetes, 2002 - Am Diabetes Assoc The rise in obesity and its complications has generated enormous interest in the regulation of
feeding and body weight. We show that a spermine metabolite of cholesterol (MSI-1436) decreases
body weight, specifically fat, by suppressing feeding and preventing the reduction in ... Cited by 10 - Related articles - BL Direct - All 6 versions
M Zasloff, JI Williams, Q Chen, M Anderson, T … - International journal of …, 2001 - ncbi.nlm.nih.gov OBJECTIVE: We describe the pharmacological properties of a novel spermine-cholesterol
adduct, MSI 1436 (3beta-N-1(spermine)-7alpha, 24R-dihydroxy-5alpha-cholestane
24-sulfate), which causes reversible suppression of food and fluid intake in mammals ... Cited by 9 - Related articles - BL Direct - All 4 versions
- ►physiology.org MN Chernova, DH Vandorpe, JS Clark, JI … - American Journal of …, 2005 - Am Physiological Soc The shark liver antimicrobial polyaminosterol squalamine is an angiogenesis inhibitor under
clinical investigation as an anti-cancer agent and as a treatment for the choroidal neovascularization
associated with macular degeneration of the retina. The related polyaminosterol ... Cited by 2 - Related articles - BL Direct - All 5 versions
PJ Ala, L Gonneville, MC Hillman, M Becker-Pasha, … - Journal of Biological …, 2006 - ASBMB Crystal structures of protein-tyrosine phosphatase 1B in complex with compounds bearing a
novel isothiazolidinone (IZD) heterocyclic phosphonate mimetic reveal that the heterocycle is
highly complementary to the catalytic pocket of the protein. The heterocycle participates in ... Cited by 3 - Related articles - All 7 versions
- ►jbc.org PJ Ala, L Gonneville, M Hillman, M Becker-Pasha, … - Journal of Biological …, 2006 - ASBMB Structural analyses of the protein-tyrosine phosphatase 1B (PTP1B) active site and inhibitor complexes
have aided in optimization of a peptide inhibitor containing the novel (S)-isothiazolidinone
(IZD) phosphonate mimetic. Potency and permeability were simultaneously improved by ... Cited by 5 - Related articles - All 6 versions
- ►genaera.com [PDF] N Takahashi, Y Qi, HR Patel, RS Ahima - Journal of hepatology, 2004 - Elsevier 1436 decreased body weight, specifically fat content, by inhibiting food intake and increasing
energy expenditure. In contrast to weight loss from food restriction, this aminosterol specifically
lowered circulating lipids, reversed hepatic steatosis and normalized alanine ... Cited by 16 - Related articles - All 7 versions
ZK Wan, B Follows, S Kirincich, D Wilson, E Binnun, … - Bioorganic & Medicinal …, 2007 - Elsevier The following account describes our systematic effort to replace one of the carboxylate groups
of our diacid thiophene PTP1B inhibitors. Active hits were validated using enzymatic assays
before pursuing efforts to improve the potency. Only when the C2 carboxylic acid was ... Cited by 8 - Related articles - All 3 versions
RB Sparks, P Polam, W Zhu, ML Crawley, A … - Bioorganic & Medicinal …, 2007 - Elsevier Benzothiazole benzimidazole (S)-isothiazolidinone ((S)-IZD) derivatives 5 were discovered through
a peptidomimetic modification of the tripeptide (S)-IZD protein tyrosine phosphatase 1B
(PTP1B) inhibitor 1. These derivatives are potent, competitive, and reversible inhibitors of ... Cited by 8 - Related articles - All 4 versions
- ►genaera.com [PDF] RD HIGGINS, YUN YAN, Y GENG, M ZASLOFF, … - Pediatric …, 2004 - journals.lww.com The goal of this study was to determine whether an antian- giogenic agent, squalamine, given
late during the evolution of oxygen-induced retinopathy (OIR) in the mouse, could improve retinal
neovascularization. OIR was induced in neonatal C57BL6 mice and the neonates were ... Cited by 9 - Related articles - BL Direct - All 4 versions
