DG Alleva, A Gaur, L Jin, D Wegmann, PA … - Diabetes, 2002 - Am Diabetes Assoc The nonobese diabetic (NOD) mouse is a good model for human type 1 diabetes,
which is characterized by autoreactive T-cell-mediated destruction of
insulin-producing islet β-cells of the pancreas. The 9–23 amino acid ... Cited by 69 - Related articles - BL Direct - All 4 versions
DG Alleva, RA Maki, AL Putnam, JM Robinson … - Scandinavian Journal of Immunology, 2006 - interscience.wiley.com NBI-6024 is an altered peptide ligand (APL) corresponding to the 9–23 amino
acid region of the insulin B chain (B (9−23) ), an epitope recognized by
inflammatory interferon-γ-producing T helper (Th)1 lymphocytes in type 1 ... Cited by 20 - Related articles - BL Direct - All 6 versions
[CITATION] Peptide and MHC specific breaking of humoral tolerance to native insulin with the B: 9-23 …
- ►nih.gov E Liu, H Moriyama, N Abiru, D Miao, L Yu, RM … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig There is evidence that amino acids 9–23 of the insulin B chain are a major
target of anti-islet autoimmunity in type 1 diabetes. Administration of this
peptide to NOD mice prevents diabetes, and phase I trials of an altered ... Cited by 56 - Related articles - BL Direct - All 8 versions
- ►nih.gov H Moriyama, N Abiru, J Paronen, K Sikora, E … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences It has been reported that an insulin 2 gene knockout, when bred onto nonobese
diabetic (NOD) mice, accelerates diabetes. We produced insulin 1 gene knockout
congenic NOD mice. In contrast to insulin 2, diabetes and insulitis were ... Cited by 79 - Related articles - BL Direct - All 10 versions
N Abiru, D Wegmann, E Kawasaki, P Gottlieb, … - Journal of Autoimmunity, 2000 - Elsevier T cells isolated from islets of non-obese diabetic (NOD) mice are enriched for
insulin-reactive cells. The great majority of these T cells recognize insulin B
chain peptide (B:9–23). B:9–23 reactive T cell clones are diabetogenic ... Cited by 35 - Related articles - BL Direct - All 5 versions
- ►milray.org [PDF] - Free from Publisher LC Harrison, MC Honeyman, CE Steele, NL … - Diabetes Care, 2004 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—A total of 38 individuals, median age 10.8 years,
with antibodies to one or more pancreatic islet antigens (insulin, GAD65, or
tyrosine phosphatase-like insulinoma antigen 2) were randomized to ... Cited by 33 - Related articles - BL Direct - All 8 versions
- ►pnas.org H Moriyama, L Wen, N Abiru, E Liu, L Yu, D … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences Polyinosinic-polycytidylic acid (PolyIC), a “mimic” of double-stranded viral
RNA, can induce diabetes when administered to rats with RT1 u , and immunization
of normal H-2 d mice (eg, BALB/c) with insulin B:9–23 peptide (but not ... Cited by 85 - Related articles - BL Direct - All 8 versions
M Bowman, M Atkinson - Diabetologia, 2002 - Springer In terms of therapeutic efficacy, no whole protein or peptide administered at 12
or 15 weeks of age altered the frequency of Type I diabetes (Fig. 1).
Specifically, there were no differences in the cumulative diabetes ... Cited by 7 - Related articles - All 3 versions
E Jaeckel, MA Lipes, H von Boehmer - Insulin (pmol/l) - microbio.uab.edu Although autoimmune diseases can be initiated by immunization with a single
antigen, it is not clear whether a single self antigen is essential for the
initiation and, perhaps, the perpetuation of spontaneous autoimmunity. Some ... Cited by 55 - Related articles - BL Direct - All 7 versions
