- ►diabetesjournals.org O Boulard, D Damotte, N Deruytter, G … - Diabetes, 2002 - Am Diabetes Assoc The major histocompatibility complex (MHC) has long been associated with
predisposition to several autoimmune diseases, including type 1 diabetes and
autoimmune thyroiditis. In type 1 diabetes, a primary role has been ... Cited by 18 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] CE Mathews, RT Graser, DV Serreze, EH … - Diabetes, 2000 - Am Diabetes Assoc MHC class II region identity with the H 2 g 7 haplotype of NOD mice. However,
CTS mice were reported to express distinct but undefined MHC class I gene prod-
ucts. Because diabetes frequency was reduced 56% in females of a NOD stock ... Cited by 19 - Related articles - BL Direct - All 3 versions
N Babaya, H Ikegami, T Fujisawa, H Ueda, K … - Autoimmunity, 2002 - informahealthcare.com Autoimmune type 1 diabetes is caused by specific destruction of the pancreatic b
cells. Although the precise mechanism of b cell destruction is still under
investi- gation, it is known that autoimmunity plays a major role in the ... Cited by 10 - Related articles - BL Direct - All 7 versions
N Babaya, H Ikegami, Y Kawaguchi, T … - INTERNATIONAL JOURNAL OF DIABETES, 2000 - ijod.uaeu.ac.ae By using a congenic non-obese diabetic (NOD) mouse strain that possesses a
recombinant major histocompatibility complex (MHC) from a diabetes-resistant
sister strain, the CTS mouse, we have previously mapped a second component ... Cited by 8 - Related articles - View as HTML - BL Direct - All 2 versions
- ►jimmunol.org [PDF] M Hattori, E Yamato, N Itoh, H Senpuku, T … - The Journal of Immunology, 1999 - Am Assoc Immnol To localize the MHC-linked diabetogenic genes in the nono- bese diabetic (NOD)
mouse, a recombinational hotspot from the B10.A(R209) mouse was introduced to
the region between the MHC class IK and class II A of the NOD mouse with ... Cited by 38 - Related articles - BL Direct - All 3 versions
K Inoue, H Ikegami, T Fujisawa, S Noso, K … - Diabetologia, 2004 - Springer Aims/hypothesis. Recent studies have revealed that MHC-linked susceptibility to
Type 1 diabetes is deter- mined by multiple components. In the non-obese dia-
betic (NOD) mouse, a second component (Idd16) has been mapped to a region ... Cited by 10 - Related articles - BL Direct - All 4 versions
[CITATION] Homologous recombination of the MHC class IK region defines new MHC-linked diabetogenic …
- ►jimmunol.org T Takaki, SM Lieberman, TM Holl, B Han, P … - The Journal of Immunology, 2004 - Am Assoc Immnol The NOD mouse is a model for autoimmune type 1 diabetes in humans. CD8 + T cells
are essential for the destruction of the insulin-producing pancreatic cells
characterizing this disease. AI4 is a pathogenic CD8 + T cell clone, ... Cited by 11 - Related articles - BL Direct - All 4 versions
S Thiessen, P Serra, A Amrani, J Verdaguer, … - Diabetes, 2002 - Am Diabetes Assoc For poorly understood reasons, the development of autoimmune diabetes in humans
and mice is dominantly inhibited by major histocompatibility complex (MHC) class
II molecules with diverse antigen-binding sites. We have previously shown ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org A Ueno, S Cho, L Cheng, Z Wang, B Wang, Y … - The Journal of Immunology, 2005 - Am Assoc Immnol Polymorphism of MHC and MHC-linked genes is tightly associated with
susceptibility to type 1 diabetes (T1D) in human and animal models. Despite the
extensive studies, however, the role of MHC and MHC-linked genes expressed ... Cited by 3 - Related articles - BL Direct - All 5 versions
