- ►diabetesjournals.org M Hawkins, I Gabriely, R Wozniak, K Reddy, L Rossetti, … - Diabetes, 2002 - Am Diabetes Assoc Glucose effectiveness is impaired in type 2 diabetes. We hypothesize that chronic hyperglycemia
and hyperlipidemia contribute importantly to this defect. To test this hypothesis, we compared
the effect of acute hyperglycemia on glucose turnover in type 2 diabetic subjects in good ... Cited by 29 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org M Hawkins, J Tonelli, P Kishore, D Stein, E Ragucci, A … - Diabetes, 2003 - Am Diabetes Assoc Increased circulating free fatty acids (FFAs) inhibit both hepatic and peripheral insulin action.
Because the loss of effectiveness of glucose to suppress endogenous glucose production and
stimulate glucose uptake contributes importantly to fasting hyperglycemia in type 2 ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] M Mevorach, A Giacca, Y Aharon, M … - Journal of Clinical …, 1998 - pubmedcentral.nih.gov We examined the ability of an equivalent increase in circu- lating glucose concentrations to inhibit
endogenous glucose production (EGP) and to stimulate glucose metabolism in patients with
Type 2 diabetes mellitus (DM2). Somatostatin was infused in the presence of basal ... Cited by 74 - Related articles - BL Direct - All 10 versions
MF Nielsen, R Basu, S Wise, A Caumo, C … - DIABETES-NEW …, 1998 - Am Diabetes Assoc The present studies were undertaken to determine whether people with type 2 diabetes are resistant
to the effects of glucose as well as insulin. Diabetic and nondiabetic subjects were studied on
three occasions. Hormone secretion was inhibited with somatostatin. Insulin ... Cited by 45 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] JN Clore, J Stillman, H Sugerman - Diabetes, 2000 - Am Diabetes Assoc Despite the effects of hyperinsulinemia and hypergly- cemia, 2 factors known to inhibit endogenous
glucose production (EGP) in nondiabetic subjects, increased EGP is a consistent feature of type
2 diabetes. Recent studies have suggested that increased glucose-6-phos- phatase ( ... Cited by 38 - Related articles - BL Direct - All 4 versions
- ►physiology.org A Vella, AS Reed, N Charkoudian, P Shah … - American Journal of …, 2003 - Am Physiological Soc To determine whether, in the presence of constant insulin concentrations, a change in glucose
concentrations results in a reciprocal change in endogenous glucose production (EGP), glucagon
( 130 ng/l) and insulin ( 65 pmol/l) were maintained at constant "basal" concentrations ... Cited by 18 - Related articles - BL Direct - All 4 versions
S Del Prato, A Riccio, S Vigili de … - American Journal of …, 1995 - Am Physiological Soc Basal plasma insulin levels exert a qualitative but not ... STEFANO DEL PRATO, ANTONIO
RICCIO, SAULA VIGIL1 DE KREUTZENBERG, MAURO DORELLA, ANTONIO TIENGO, AND
RALPH A. DEFRONZO Cattedra di Malattie de1 Metabolismo, University of Padova, ... Cited by 20 - Related articles - BL Direct - All 4 versions
S Nagasaka, K Tokuyama, I Kusaka, H … - DIABETES-NEW …, 1999 - Am Diabetes Assoc Insulin sensitivity, glucose effectiveness, and endoge- nous glucose production (EGP) during
stable-labeled, frequently sampled insulin-modified intravenous glu- cose tolerance test
(FSIGT) were evaluated by a single- and two-compartment minimal model combined with ... Cited by 37 - Related articles - BL Direct - All 6 versions
- ►physiology.org L Rossetti, W Chen, M Hu, M Hawkins, N … - American Journal of …, 1997 - Am Physiological Soc Glucokinase (GK) catalyzes the phosphorylation of glucose in -cells and hepatocytes, and mutations
in the GK gene have been implicated in a form of human diabetes. To investigate the relative
role of partial deficiencies in the hepatic vs. pancreatic GK activity, we examined insulin ... Cited by 25 - Related articles - BL Direct - All 4 versions
M Hawkins, I Gabriely, R Wozniak, C Vilcu, H Shamoon … - Diabetes, 2002 - Am Diabetes Assoc The ability of hyperglycemia per se to suppress endogenous glucose production (GP) is blunted
in type 2 diabetes. This could be due in part to decreased glucose-induced flux through glucokinase
(GK). Because fructose activates hepatic GK, we examined whether catalytic amounts of ... Cited by 41 - Related articles - BL Direct - All 6 versions
