- ►diabetesjournals.org ES Buhl, N Jessen, R Pold, T Ledet, A Flyvbjerg, SB … - Diabetes, 2002 - Am Diabetes Assoc The insulin resistance syndrome is characterized by several risk factors for cardiovascular
disease. Chronic chemical activation of AMP-activated protein kinase by the adenosine analog
5-aminoimidazole-4-carboxamide-1-β -d-ribofuranoside (AICAR) has been shown to ... Cited by 93 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org R Bergeron, SF Previs, GW Cline, P Perret, RR Russell … - Diabetes, 2001 - Am Diabetes Assoc Activation of AMP-activated protein kinase (AMPK) with 5-aminoimidazole-4-carboxamide-1-β
-d-ribofuranoside (AICAR) increases glucose transport in skeletal muscle via an insulin-independent
pathway. To examine the effects of AMPK activation on skeletal muscle glucose transport ... Cited by 134 - Related articles - BL Direct - All 4 versions
MA Iglesias, JM Ye, G Frangioudakis, AK Saha, E … - Diabetes, 2002 - Am Diabetes Assoc Exercise improves insulin sensitivity. As AMP-activated protein kinase (AMPK) plays an important
role in muscle metabolism during exercise, we investigated the effects of the AMPK activator
5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) on insulin action in ... Cited by 145 - Related articles - BL Direct - All 5 versions
XM Song, M Fiedler, D Galuska, JW Ryder, M … - Diabetologia, 2002 - Springer Type II (non-insulin-dependent) diabetes mellitus is one of the major causes of disability and
death, these being due to the complications accompanying the dis- ease, [1]. Today, the therapeutic
tools commonly uti- lised to treat Type II diabetes mellitus include diet, exercise, ... Cited by 76 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org R Pold, LS Jensen, N Jessen, ES Buhl, O Schmitz, A … - Diabetes, 2005 - Am Diabetes Assoc Lifestyle interventions including exercise programs are cornerstones in the prevention of
obesity-related diabetes. The AMP-activated protein kinase (AMPK) has been proposed to be
responsible for many of the beneficial effects of exercise on glucose and lipid metabolism. ... Cited by 58 - Related articles - All 7 versions
AE Halseth, NJ Ensor, TA White, SA Ross, EA … - … and Biophysical Research …, 2002 - Elsevier The enzyme 5 ′ AMP-activated protein kinase (AMPK) is activated by increases in intracellular
AMP concentration through a complex interaction of phosphorylation and allosteric
regulation. Actions of AMPK elucidated thus far suggest that AMPK may be a viable target ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org DJ Cuthbertson, JA Babraj, KJW Mustard, MC Towler, … - Diabetes, 2007 - Am Diabetes Assoc Activation of AMP-activated protein kinase (AMPK) in rodent muscle by exercise, metformin,
5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR), and adiponectin increases
glucose uptake. The aim of this study was to determine whether AICAR stimulates muscle ... Cited by 21 - Related articles - BL Direct - All 6 versions
B Cool, B Zinker, W Chiou, L Kifle, N Cao, M Perham, R … - Cell metabolism, 2006 - Elsevier AMP-activated protein kinase (AMPK) is a key sensor and regulator of intracellular and
whole-body energy metabolism. We have identified a thienopyridone family of AMPK
activators. A-769662 directly stimulated partially purified rat liver AMPK (EC 50 = 0.8 μM) ... Cited by 91 - Related articles - All 9 versions
- ►physiology.org WW Winder, BF Holmes, DS Rubink, EB … - Journal of applied …, 2000 - Am Physiological Soc Muscle contraction causes an increase in activity of 5'-AMP-activated protein kinase (AMPK).
This study was designed to determine whether chronic chemical activation of AMPK will increase
mitochondrial enzymes, GLUT-4, and hexokinase in different types of skeletal muscle of ... Cited by 298 - Related articles - BL Direct - All 5 versions
X Yu, S McCorkle, M Wang, Y Lee, J Li, AK Saha, RH … - Diabetologia, 2004 - Springer Aims/hypothesis. Leptin has been shown to activate AMP-activated protein kinase (AMPK), an
enzyme that regulates the activities of key enzymes of lipid synthesis and metabolism. We assess
here (i) whether AMPK activity is diminished in rodents deficient in leptin or the leptin ... Cited by 56 - Related articles - All 3 versions
