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Scholar Results 1 - 10 of about 101 related to Freshwater: Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia.... (0.20 sec) 

Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic …

- diabetesjournals.org
JD Freshwater, CI Svensson, AB Malmberg, … - Diabetes, 2002 - Am Diabetes Assoc
Diabetic rats display exaggerated hyperalgesic behavior in response to noxious
stimuli that may model aspects of painful diabetic neuropathy. This study
examined the contribution of spinal prostaglandin production to this ...
Cited by 35 - Related articles - BL Direct - All 4 versions

Elevated substance-P-like immunoreactivity levels in spinal dialysates during the formalin …


NA Calcutt, CO Stiller, H Gustafsson, AB … - Brain research, 2000 - Elsevier
Content-length: 1367. ...
Cited by 32 - Related articles - All 4 versions

Pain behavior and response properties of spinal dorsal horn neurons following experimental …


A Pertovaara, H Wei, J Kalmari, M … - Experimental neurology, 2001 - Elsevier
We attempted to characterize a spinal neuronal correlate of painful neuropathy
induced by diabetes mellitus (DM). Pain behavior and response properties of
spinal dorsal horn neurons were determined in rats with a ...
Cited by 31 - Related articles - BL Direct - All 8 versions

Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate …


A Matsunaga, M Kawamoto, S Shiraishi, T … - European journal of pharmacology, 2007 - Elsevier
Members of the cyclooxygenase (COX) family are known to catalyze the
rate-limiting steps of prostaglandins synthesis and reported to be involved in
neuropathic pain. Diabetic neuropathy is a type of neuropathic pain, though ...
Cited by 17 - Related articles - All 5 versions

Gabapentin prevents hyperalgesia during the formalin test in diabetic rats

- kappa.ro [PDF] 
RM Cesena, NA Calcutt - Neuroscience letters, 1999 - Elsevier
The anticonvulsant agent gabapentin exhibits antihyperalgesic properties in
animal models of neuropathic pain. Diabetic rats display increased nocifensive
behavior during the formalin test of persistent chemical irritation to the ...
Cited by 33 - Related articles - All 6 versions

Protection of sensory function and antihyperalgesic properties of a prosaposin-derived …


NA Calcutt, JD Freshwater, JS O'Brien - Anesthesiology, 2000 - journals.lww.com
Cited by 22 - Related articles - BL Direct - All 3 versions

Potential mechanisms of neuropathic pain in diabetes.


NA Calcutt - International review of neurobiology, 2002 - ncbi.nlm.nih.gov
Abnormal sensations and pain are features of approximately 10% of all cases of
diabvetic neuropathy and can cause marked diminution in the quality of life for
these patients. The quality and distribution of pain are variable, although ...
Cited by 40 - Related articles - BL Direct

Different effects of two aldose reductase inhibitors on nociception and prostaglandin E


NA Calcutt, L Li, TL Yaksh, AB Malmberg - European journal of pharmacology, 1995 - Elsevier
This study examined the effect of two structurally dissimilar aldose reductase
inhibitors, N-[[5-(trifluoromethyl)-6-methoxy-1-napthalenyl]thioxomethyl]-N-
methlyglycine (tolrestat) and 4-amino-2,6-dimethylphenyl-sulphonyl ...
Cited by 35 - Related articles - All 4 versions

Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase …


NA Calcutt, JD Freshwater, AP Mizisin - Diabetologia, 2004 - Springer
Aims/hypothesis. Sensory neuropathy in diabetic pa- tients frequently presents
itself as progressive loss of thermal perception, while some patients describe
con- current spontaneous pain, allodynia or hyperalgesia. Diabetic rats ...
Cited by 48 - Related articles - BL Direct - All 7 versions

Pathogenesis of spinally mediated hyperalgesia in diabetes


KM Ramos, Y Jiang, CI Svensson, NA Calcutt - Diabetes, 2007 - Am Diabetes Assoc
Hyperalgesia to noxious stimuli is accompanied by increased spinal
cyclooxygenase (COX)-2 protein in diabetic rats. The present studies were
initiated to establish causality between increased spinal COX-2 activity ...
Cited by 13 - Related articles - BL Direct - All 5 versions


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