- ►diabetesjournals.org N Begum, OA Sandu, N Duddy - Diabetes, 2002 - Am Diabetes Assoc Recent studies from our laboratory have shown that insulin induces relaxation of vascular smooth
muscle cells (VSMCs) via stimulation of myosin phosphatase and inhibition of Rho kinase
activity. In this study, we examined the mechanism whereby insulin inhibits Rho signaling ... Cited by 31 - Related articles - BL Direct - All 5 versions
- ►physiology.org OA Sandu, M Ito, N Begum - Journal of Applied Physiology, 2001 - Am Physiological Soc Our laboratory has recently demonstrated that insulin induces relaxation of vascular smooth
muscle cells (VSMCs) by activating myosin-bound phosphatase (MBP) and by inhibiting Rho
kinase (Begum N, Duddy N, Sandu OA, Reinzie J, and Ragolia L. Mol Endocrinol 14: ... Cited by 9 - Related articles - All 3 versions
- ►physiology.org JH Lee, L Ragolia - American Journal of Physiology- Cell …, 2006 - Am Physiological Soc Insulin resistance, a major factor in the development of type 2 diabetes, is known to be associated
with defects in blood vessel relaxation. The role of Akt on insulin-induced relaxation of vascular
smooth muscle cell (VSMC) was investigated using siRNA targeting Akt (siAKTc) and ... Cited by 13 - Related articles - BL Direct - All 4 versions
OA Sandu, M Ito, N Begum - … of applied physiology (Bethesda, Md.: 1985 …, 2001 - ncbi.nlm.nih.gov Our laboratory has recently demonstrated that insulin induces relaxation of vascular smooth
muscle cells (VSMCs) by activating myosin-bound phosphatase (MBP) and by inhibiting Rho
kinase (Begum N, Duddy N, Sandu OA, Reinzie J, and Ragolia L. Mol Endocrinol 14: ... Cited by 29 - Related articles - BL Direct
- ►physiology.org A Jacob, A Smolenski, SM Lohmann, N … - American Journal of …, 2004 - Am Physiological Soc Diabetes mellitus is a major risk factor in the development of atherosclerosis and cardiovascular
disease conditions, involving intimal injury and enhanced vascular smooth muscle cell
(VSMC) migration. We report a mechanistic basis for divergences between insulin's ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►endojournals.org N Begum, N Duddy, O Sandu, J Reinzie, L … - Molecular …, 2000 - Endocrine Soc In this study, we examined the molecular mechanism of myosin-bound protein phosphatase
(MBP) regulation by insulin and evaluated the role of MBP in insulin-mediated
vasorelaxation. Insulin rapidly stimulated MBP in confluent primary vascular smooth ... Cited by 33 - Related articles - BL Direct - All 2 versions
G Loirand, C Guilluy, P Pacaud - Trends in Cardiovascular Medicine, 2006 - Elsevier The small G protein Rho signaling pathways are recognized as major regulators of cardiovascular
functions, and activation of Rho proteins appears to be a common component for the pathogenesis
of hypertension and vascular proliferative disorders. Rho proteins are tightly regulated, ... Cited by 17 - Related articles - All 6 versions
N Begum - Front Biosci, 2003 - bioscience.org 1. Abstract 2. Introduction 3. Molecular basis of Insulin-induced Vasorelaxation 3.1. Role of myosin
bound phosphatase 3.2. Regulation of myosin phosphatase by its targeting subunit, MBS
3.3. Role of Nitric Oxide/cGMP signaling in myosin phosphatase activation via MBS 3.4. ... Cited by 10 - Related articles - View as HTML - All 3 versions
N Begum, L Ragolia, J Rienzie, M McCarthy, N … - Journal of Biological …, 1998 - ASBMB In this study, we examined the regulation of mitogen-activated protein kinase phosphatase
(MKP-1) expression by insulin in primary vascular smooth muscle cell cultures. Insulin caused
a rapid time- and dose-dependent induction of MKP-1 mRNA and protein expression. ... Cited by 68 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org AM Kahn, A Husid, JC Allen, CL Seidel, T Song - Hypertension, 1997 - Am Heart Assoc Abstract Insulin acutely decreases contractile agonist-induced Ca 2+ influx and contraction in
endothelium-free cultured vascular smooth muscle (VSM) cells, but the mechanism is not
known. Since it has been reported that insulin-induced vasodilation in humans is linked to ... Cited by 31 - Related articles - BL Direct - All 5 versions
