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Scholar Results 1 - 10 of about 101 related to Thirone: Modulation of growth hormone signal transduction in kidneys of streptozotocin-induced.... (0.09 sec) 

Modulation of growth hormone signal transduction in kidneys of streptozotocin-induced …


ACP Thirone, JA Scarlett, AL Gasparetti, EP … - Diabetes, 2002 - Am Diabetes Assoc
Growth hormone (GH) and IGFs have a long distinguished history in diabetes, with
possible participation in the development of renal complications. The implicated
effect of GH in diabetic end-stage organ damage may be mediated by growth ...
Cited by 22 - Related articles - BL Direct - All 4 versions

Protection against diabetes-induced nephropathy in growth hormone receptor/binding …

- endojournals.org
LL Bellush, S Doublier, AN Holland, LJ Striker … - Endocrinology, 2000 - Endocrine Soc
To further investigate the role of GH in diabetic nephropathy, experimental
diabetes was induced with streptozotocin (STZ) in mice in which the GH
receptor/binding protein gene was disrupted. Body weight, blood glucose, ...
Cited by 42 - Related articles - BL Direct - All 3 versions

High glucose, high insulin, and their combination rapidly induce laminin-β1 synthesis by …

- diabetesjournals.org
MM Mariappan, D Feliers, S Mummidi, GG … - Diabetes, 2007 - Am Diabetes Assoc
Laminin is a glycoprotein that contributes to renal extracellular matrix
expansion in diabetes. We investigated regulation of laminin-β1 synthesis in
murine renal proximal tubular epithelial cells by 30 mmol/l glucose (high ...
Cited by 14 - Related articles - BL Direct - All 6 versions

mRNA translation: unexplored territory in renal science

- asnjournals.org
… , MM Mariappan, K Sataranatarajan, MJ Lee, … - Journal of the American Society of Nephrology, 2006 - Am Soc Nephrol
Ambient protein levels are under coordinated control of transcription, mRNA
translation, and degradation. Whereas transcription and degradation mechanisms
have been studied in depth in renal science, the role of mRNA translation, ...
Cited by 14 - Related articles - BL Direct - All 5 versions

[CITATION] The study of experimental diabetic rat model induced with Streptozotocin


DM Yu, R Wu, W Yin, Y Yuan - Chin J Diabetes, 1995
Cited by 2 - Related articles

[CITATION] ZIERATH JR: Improved glucose tolerance restores insulin-stimulated Akt kinase activity and …


A KROOK, Y KAWANO, XM SONG, S … - Diabetes, 1997
Cited by 2 - Related articles

The effect of growth hormone on the development of diabetic kidney disease in rats

- oxfordjournals.org
D Landau, E Israel, I Rivkis, L Kachko, BF … - Nephrology Dialysis Transplantation, 2003 - ERA-EDTA
Results. The usual renal hypertrophy seen in D animals was more pronounced in
the DGH group. Creatinine clearance increased only in the D rats, but not in the
other groups, including DGH. Albuminuria was observed in the D animals but ...
Cited by 15 - Related articles - BL Direct - All 4 versions

Rapamycin prevents early steps of the development of diabetic nephropathy in rats


Y Yang, J Wang, L Qin, Z Shou, J Zhao, H … - Am J Nephrol, 2007 - content.karger.com
Background/Aims: Recent studies suggested the involvement of the Akt/mammalian
target of rapamycin (mTOR) pathway in the pathogenesis of diabetic nephropathy.
The effect of mTOR blockade by rapamycin in diabetic nephropathy was ...
Cited by 16 - Related articles - BL Direct - All 5 versions

New concepts: growth hormone, insulin-like growth factor-I and the kidney


R Rabkin, F Schaefer - Growth Hormone & IGF Research, 2004 - Elsevier
Both growth hormone (GH) and IGF-1 have major effects on normal kidney growth,
structure and function and participate in the pathogenesis of certain kidney
diseases. Furthermore when the kidneys fail there are profound changes in ...
Cited by 19 - Related articles - All 3 versions

Regulation of elongation phase of mRNA translation in diabetic nephropathy: amelioration …

- amjpathol.org
K Sataranatarajan, MM Mariappan, MJ Lee, D … - American Journal of Pathology, 2007 - ASIP
High glucose and high insulin, pathogenic factors in type 2 diabetes, induce
rapid synthesis of the matrix protein laminin-β1 in renal proximal tubular
epithelial cells by stimulation of initiation phase of mRNA translation. We ...
Cited by 7 - Related articles - BL Direct - All 7 versions


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