A Davoodi-Semiromi, JJ Yang, JX She - Diabetes, 2002 - Am Diabetes Assoc The IL-12p40 locus has recently been shown to be associated with type 1 diabetes
(1). Here, we report the identification of novel microsatellite and
single-nucleotide polymorphisms (SNPs) within the IL-12p40 gene and a ... Cited by 40 - Related articles - BL Direct - All 4 versions
L Nisticò, G Giorgi, M Giordano, A Galgani, A … - Diabetes, 2002 - Am Diabetes Assoc Linkage with chromosome 5q33–34 was recently detected in 249 sib-pairs from
187 British and Australian multiplex families (5). Two noncoding polymorphisms
of the interleukin 12B (IL12B) gene, mapping in the linked region, were ... Cited by 19 - Related articles - BL Direct - All 6 versions
RM McCormack, AP Maxwell, DJ Carson, CC … - Genes and immunity, 2002 - ncbi.nlm.nih.gov A recent study employing Australian and UK type 1 diabetes families has
demonstrated significant transmission bias to affected offspring of a
polymorphism (1188A allele; termed allele 1) in the 3' untranslated region ... Cited by 21 - Related articles - BL Direct
L Windsor, G Morahan, D Huang, V McCann, T … - Human immunology, 2004 - Elsevier Carriage of a polymorphism in the 3′untranslated region of the IL12B gene
encoding IL-12p40 was investigated in subjects with type 1 diabetes mellitus
stratified by age at diagnosis (n = 648) and compared with a ... Cited by 23 - Related articles - All 3 versions
- ►bmj.com R Bergholdt, P Ghandil, J Johannesen, OP … - British Medical Journal, 2004 - jmg.bmj.com Confirmation of the significance of the IL12B 3'UTR polymorphism in T1DM in
other populations is important. The aims of our study were to seek confirmation
of the involvement of the IL12B C1159A SNP in T1DM susceptibility in a ... Cited by 22 - Related articles - All 5 versions
S Johansson, BA Lie, E Thorsby, DE Undlien - Immunogenetics, 2001 - Springer Type 1 diabetes (T1DM) is a multifactorial disease and both genetic and
environmental factors contribute to the pathogenesis. The HLA complex (IDDM1)
encodes a major part of the genetic predisposition, but a number of other ... Cited by 15 - Related articles - BL Direct - All 3 versions
D Huang, MR Cancilla, G Morahan - Genes and immunity, 2000 - ncbi.nlm.nih.gov Owing to the importance of interleukin (IL)-12 in regulating immune responses,
we have determined the complete genomic sequence and organization of the gene
encoding its p40 subunit. The genomic sequence was determined and was ... Cited by 68 - Related articles - BL Direct
D Seegers, A Zwiers, W Strober, AS Peña, … - Genes and immunity, 2002 - ncbi.nlm.nih.gov Interleukin-12 (IL-12) is a key cytokine for the induction of Th1 immune
responses. We evaluated whether a TaqI polymorphism in the 3'UTR of the IL-12
p40 gene affects secretion of IL-12 in vitro, and whether this polymorphism ... Cited by 76 - Related articles - BL Direct
G Morahan, D Huang, SI Ymer, MR Cancilla, … - Nat Genet, 2001 - autoimmune.pathology.jhmi.edu Type 1 diabetes (T1D; or insulin-dependent diabetes mellitus, IDDM) is an
autoimmune disease with both genetic and environ- mental components. In addition
to the human leukocyte antigen (HLA) complex, the single major genetic ... Cited by 195 - Related articles - View as HTML - BL Direct - All 5 versions
MA Hall, E McGlinn, G Coakley, SA Fisher, K … - Genes and immunity, 2000 - ncbi.nlm.nih.gov Understanding of the genetic basis of autoimmune diseases is currently
incomplete. Cytokine gene polymorphisms warrant consideration as factors
explaining variation in the human immune and inflammatory responses and as ... Cited by 93 - Related articles - BL Direct
