M Stumvoll, H Häring - Diabetes, 2002 - Am Diabetes Assoc Peroxisome proliferator-activated receptor (PPAR)-γ is a transcription factor with a key role in
adipocyte differentiation. The Ala allele of the common Pro12Ala polymorphism in the isoform
PPAR-γ2 is associated with reduced risk for type 2 diabetes. The effect on the individual ... Cited by 187 - Related articles - BL Direct - All 5 versions
PA Polymorphism - DIABETES, 2002 - Am Diabetes Assoc Peroxisome proliferator–activated receptor (PPAR)- is a transcription factor with a key role in
adipocyte differentiation. The Ala allele of the common Pro12Ala polymorphism in the isoform
PPAR- 2 is associated with reduced risk for type 2 diabetes. The effect on the individual is ... Related articles
- ►diabetesjournals.org H Mori, H Ikegami, Y Kawaguchi, S Seino, N Yokoi, J … - Diabetes, 2001 - Am Diabetes Assoc The allele frequencies for a Pro 12 →Ala substitution in peroxisome proliferator–activated
receptor-γ differ among ethnic groups, and its relationship with diabetes and associated diseases
is controversial. The prevalence of this polymorphism and its effects on clinical ... Cited by 163 - Related articles - BL Direct - All 5 versions
CJ Yen, BA Beamer, C Negri, K Silver, KA Brown, … - … and biophysical research …, 1997 - Elsevier Peroxisome proliferator activated receptor-gamma (PPARγ) is a nuclear receptor that regulates
adipocyte differentiation, and possibly lipid metabolism and insulin sensitivity. As such, PPARγ
is a promising candidate gene for several human disorders including obesity and type 2 ... Cited by 268 - Related articles - BL Direct - All 5 versions
BA Beamer, CJ Yen, RE Andersen, D Muller, … - DIABETES-NEW …, 1998 - Am Diabetes Assoc T he nuclear receptor, peroxisome proliferator- act i- vated receptor- ( P PA R - ), is an important
regula- tor of adipocyte differentiation and a modulator of intracellular insulin-signaling events
(1). PPA R - mRNA expression in both skeletal muscle and adipose tissue in vitro is ... Cited by 210 - Related articles - BL Direct - All 5 versions
J Masugi, Y Tamori, H Mori, T Koike, M Kasuga - Biochemical and Biophysical …, 2000 - Elsevier Peroxisome proliferator-activated receptor-γ (PPARγ) is a member of the nuclear hormone receptor
superfamily of transcription factors and appears to be a key regulator of adipogenesis. Members
of the thiazolidinedione class of insulin-sensitizing agents act as high-affinity ligands for ... Cited by 111 - Related articles - BL Direct - All 5 versions
SS Deeb, L Fajas, M Nemoto, J Pihlajamäki, L … - Nature Genetics, 1998 - nature.com The peroxisome proliferator-activated receptor- (PPAR ) is a transcription factor that has a pivotal
role in adipocyte differentiation and expression of adipocyte-specific genes 1, 3 . The PPAR 1
and 2 isoforms result from alternative splicing 4 and have ligand-dependent and - ... Cited by 756 - Related articles - BL Direct - All 4 versions
- ►endojournals.org L Frederiksen, K Brodbaek, M Fenger, T … - Journal of Clinical …, 2002 - Endocrine Soc The Pro12Ala polymorphism of PPAR- 2 has been shown to influence insulin sensitivity and
the risk of type 2 diabetes in various ethnic populations. We examined whether the polymorphism
was related to the insulin resistance syndrome (IRS) among nondiabetic Danish subjects. ... Cited by 85 - Related articles - BL Direct - All 5 versions
K Clement, S Hercberg, B Passinge, P Galan, M … - International journal of …, 2000 - cat.inist.fr OBJECTIVE: Peroxisome-proliferator-activated receptors y(PPAR y), is a key regulator of adipocyte
differentiation and energy balance. Two naturally occurring mutations in the PPAR γ gene, Pro
115 Gln and Pro 12 Ala, have recently been shown to impair the function of the PPARγ 2 ... Cited by 100 - Related articles - BL Direct - All 2 versions
J Robitaille, JP Despres, L Perusse, MC Vohl - Clinical genetics, 2003 - interscience.wiley.com The metabolic syndrome is a complex disorder characterized by an atherogenic dyslipidemia
resulting from the interaction between genetic and nutritional factors. The objective of this study
was to examine in a cohort of 720 adults participating in the Québec Family Study (QFS) ... Cited by 84 - Related articles - BL Direct - All 4 versions
