- ►diabetesjournals.org J Ferrer - Diabetes, 2002 - Am Diabetes Assoc Heterozygous mutations in the genes encoding transcriptional regulators
hepatocyte nuclear factor (HNF)-1 and HNF-4 cause a form of diabetes known as
maturity-onset diabetes of the young (MODY). Haploinsufficiency of HNF-1 or ... Cited by 58 - Related articles - BL Direct - All 5 versions
J Ferrer - DIABETES, 2002 - Am Diabetes Assoc Heterozygous mutations in the genes encoding tran- scriptional regulators
hepatocyte nuclear factor (HNF)- 1 and HNF-4 cause a form of diabetes known as
maturity-onset diabetes of the young (MODY). Haploin- sufficiency of HNF-1 ... Related articles - All 2 versions
- ►nih.gov SK Hansen, M Párrizas, ML Jensen, S Pruhova … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Mutations in the genes encoding hepatocyte nuclear factor 4α (HNF-4α) and
HNF-1α impair insulin secretion and cause maturity onset diabetes of the young
(MODY). HNF-4α is known to be an essential positive regulator of HNF-1α. ... Cited by 71 - Related articles - BL Direct - All 5 versions
SF Boj, M Párrizas, MA Maestro, J Ferrer - Proceedings of the National Academy of Sciences of …, 2001 - National Acad Sciences Mutations in the human genes encoding hepatocyte nuclear factors (HNF) 1α, 1β,
4α, and IPF1(PDX1/IDX1/STF1) result in pancreatic β cell dysfunction and
diabetes mellitus. In hepatocytes, hnf4α controls the transcription of ... Cited by 161 - Related articles - BL Direct - All 8 versions
- ►endojournals.org J Eeckhoute, E Moerman, T Bouckenooghe, B … - Endocrinology, 2003 - Endocrine Soc The nuclear receptor hepatocyte nuclear factor (HNF) 4 is involved in a
transcriptional network and plays an important role in pancreatic ß-cells.
Mutations in the HNF4 gene are correlated with maturity-onset diabetes of ... Cited by 58 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org H Thomas, K Jaschkowitz, M Bulman, TM … - Human molecular genetics, 2001 - Oxford Univ Press Maturity-onset diabetes of the young (MODY) is a monogenic, autosomal dominant
subtype of early-onset diabetes mellitus due to defective insulin secretion by
the pancreatic ß-cell in humans. Five different genes have been identified ... Cited by 154 - Related articles - BL Direct - All 6 versions
RK Gupta, KH Kaestner - Trends in Molecular Medicine, 2004 - Elsevier Diabetes mellitus is a metabolic disorder that affects over 150 million people
worldwide and is a leading cause of death in many countries. The disease can be
characterized by either absolute insulin deficiency due to the autoimmune ... Cited by 40 - Related articles - All 3 versions
T Nammo, K Yamagata, R Hamaoka, Q Zhu, T … - Diabetologia, 2002 - Springer Aims/hypothesis. One subtype of MODY (MODY3) re- sults from the heterozygous
mutation of a hepatocyte nu- clear factor (HNF)-1α. The pattern of HNF-1α
expres- sion in the normal pancreas has not been determined. This study ... Cited by 17 - Related articles - BL Direct - All 3 versions
DQ Shih, S Screenan, KN Munoz, L Philipson, … - Diabetes, 2001 - Am Diabetes Assoc Mutations in hepatocyte nuclear factor 1α (HNF-1α) lead to maturity-onset
diabetes of the young type 3 as a result of impaired insulin secretory response
in pancreatic β-cells. The expression of 50 genes essential for normal ... Cited by 141 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org LW Harries, S Ellard, A Stride… - Human Molecular Genetics, 2006 - Oxford Univ Press The generation of multiple transcripts by mRNA processing has the potential to
moderate differences in gene expression both between tissues and at different
stages of development. Where gene function is compromised by mutation, the ... Cited by 20 - Related articles - BL Direct - All 6 versions
