- ►diabetesjournals.org H Hori, T Sasaoka, H Ishihara, T Wada, S … - Diabetes, 2002 - Am Diabetes Assoc SH-2-containing inositol 5′-phosphatase 2 (SHIP-2) is a physiologically
important lipid phosphatase that functions to hydrolyze phosphatidylinositol
(PI) 3-kinase product PI(3,4,5)P3 to PI(3,4)P2 in the negative regulation ... Cited by 53 - Related articles - BL Direct - All 4 versions
T Sasaoka, H Hori, T Wada, M Ishiki, T Haruta … - Diabetologia, 2001 - Springer Activation of the PI3-kinase is known to be extreme- ly important for exerting
various metabolic actions of insulin [1ą3].PI(3,4,5)P3 produced by the
activated PI3-kinase is thought to function as a key lipid second messenger ... Cited by 52 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org E Marion, PJ Kaisaki, V Pouillon, C Gueydan, … - Diabetes, 2002 - Am Diabetes Assoc Genetic susceptibility to type 2 diabetes involves many genes, most of which are
still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of
insulin signaling and sensitivity in vivo and is thus a good candidate ... Cited by 57 - Related articles - BL Direct - All 6 versions
- ►nih.gov T Wada, T Sasaoka, M Funaki, H Hori, S … - Molecular and Cellular Biology, 2001 - Am Soc Microbiol Phosphatidylinositol (PI) 3-kinase plays an important role in various metabolic
actions of insulin including glucose uptake and glycogen synthesis. Although PI
3-kinase primarily functions as a lipid kinase which preferentially ... Cited by 106 - Related articles - BL Direct - All 5 versions
- ►endojournals.org H Ishihara, T Sasaoka, M Ishiki, T Wada, H … - Molecular Endocrinology, 2002 - Endocrine Soc Lipid phosphatase SHIP2 [Src homology 2 (SH2)-containing inositol 5'-phosphatase
2] has been shown to be a physiologically critical negative regulator of insulin
signaling. We investigated the molecular mechanism by which SHIP2 ... Cited by 22 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org PJ Kaisaki, M Delépine, PY Woon, L Sebag- … - Diabetes, 2004 - Am Diabetes Assoc Type II SH2 domain–containing inositol 5-phosphatase (INPPL1, or SHIP2) plays
an important role in the control of insulin sensitivity. INPPL1 mutations
affecting gene function have been found in rat models of type 2 diabetes ... Cited by 23 - Related articles - BL Direct - All 5 versions
H Ishihara, T Sasaoka, H Hori, T Wada, H … - Biochemical and Biophysical Research …, 1999 - Elsevier SH2-containing inositol 5′-phosphatase (SHIP) plays a negative regulatory role
in hematopoietic cells. We have now cloned the rat SHIP isozyme (SHIP2) cDNA
from skeletal muscle, which is one of the most important target tissue of ... Cited by 89 - Related articles - BL Direct - All 5 versions
MW Sleeman, KE Wortley, KMV Lai, LC Gowen, … - Nature medicine, 2005 - nature.com Genetic ablation of Inppl1, which encodes SHIP2 (SH2-domain containing inositol
5-phosphatase 2), was previously reported to induce severe insulin sensitivity,
leading to early postnatal death. In the previous study, the targeting ... Cited by 72 - Related articles - All 6 versions
X Pesesse, S Deleu, F De Smedt, L Drayer, C … - Biochemical and Biophysical Research …, 1997 - Elsevier Distinct inositol and phosphatidylinositol polyphosphates 5-phosphatases have
recently been cloned. Primers have been designed coding for highly conserved
amino acid regions that are shared between sequences of 5-phosphatases. One ... Cited by 156 - Related articles - BL Direct - All 7 versions
S Clément, U Krause, F Desmedt, JF Tanti, J … - Nature, 2001 - nature.com Insulin is the primary hormone involved in glucose homeostasis, and impairment
of insulin action and/or secretion has a critical role in the pathogenesis of
diabetes mellitus. Type-II SH2-domain-containing inositol 5-phosphatase, or ... Cited by 233 - Related articles - BL Direct - All 8 versions
