- ►diabetesjournals.org CM Rondinone, JM Trevillyan, J Clampit, RJ … - Diabetes, 2002 - Am Diabetes Assoc Protein tyrosine phosphatase 1B (PTP1B) has been implicated as a negative
regulator of insulin action. Overexpression of PTP1B protein has been observed
in insulin-resistant states associated with obesity. Mice lacking a ... Cited by 70 - Related articles - BL Direct - All 5 versions
- ►pnas.org BA Zinker, CM Rondinone, JM Trevillyan, RJ … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences The role of protein-tyrosine phosphatase 1B (PTP1B) in diabetes was investigated
using an antisense oligonucleotide in ob/ob and db/db mice. PTP1B antisense
oligonucleotide treatment normalized plasma glucose levels, postprandial ... Cited by 194 - Related articles - BL Direct - All 13 versions
- ►diabetesjournals.org RJ Gum, LL Gaede, SL Koterski, M Heindel, JE … - Diabetes, 2003 - Am Diabetes Assoc Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin
receptor (IR) signal transduction and a drug target for treatment of type 2
diabetes. Using PTP1B antisense oligonucleotides (ASOs), effects of ... Cited by 110 - Related articles - BL Direct - All 6 versions
A Cheung, J Kusari, D Jansen, D … - The Journal of laboratory and clinical medicine, 1999 - Elsevier Protein tyrosine phosphatases (PTPs) are required for the dephosphorylation of
the insulin receptor (IR) and its initial cellular substrates, and it has
recently been reported that PTP-1B may play a role in the pathogenesis of ... Cited by 43 - Related articles - BL Direct - All 6 versions
JF Waring, R Ciurlionis, JE Clampit, S Morgan … - Molecular and cellular endocrinology, 2003 - Elsevier Protein tyrosine phosphatases are important regulators of insulin signal
transduction. Our studies have shown that in insulin resistant and diabetic
ob/ob and db/db mice, reducing the levels of protein tyrosine phosphatase ... Cited by 22 - Related articles - All 4 versions
- ►nih.gov LD Klaman, O Boss, OD Peroni, JK Kim, JL … - Molecular and cellular biology, 2000 - Am Soc Microbiol Protein-tyrosine phosphatase 1B (PTP-1B) is a major protein-tyrosine phosphatase
that has been implicated in the regulation of insulin action, as well as in
other signal transduction pathways. To investigate the role of PTP-1B in ... Cited by 531 - Related articles - BL Direct - All 15 versions
- ►cell.com A Cheng, N Uetani, PD Simoncic, VP … - Developmental Cell, 2002 - Elsevier Common obesity is primarily characterized by resistance to the actions of the
hormone leptin. Mice deficient in protein tyrosine phosphatase 1B (PTP1B) are
resistant to diabetes and diet-induced obesity, prompting us to further ... Cited by 217 - Related articles - All 33 versions
- ►nih.gov R Di Paola, L Frittitta, G Miscio, M Bozzali, R … - The American Journal of Human Genetics, 2002 - Elsevier Protein tyrosine phosphatase 1B (PTP1B) inhibits insulin signaling and, when
overexpressed, plays a role in insulin resistance (Ahmad et al. 1997). We
identified, in the 3′ untranslated region of the PTP1B gene, a 1484insG ... Cited by 102 - Related articles - BL Direct - All 4 versions
SM Echwald, H Bach, H Vestergaard, B … - Diabetes, 2002 - Am Diabetes Assoc In the present study, we tested the hypothesis that variability in the protein
tyrosine phosphatase-1B (PTP-1B) gene is associated with type 2 diabetes. Using
single-strand conformational polymorphism analysis, we examined cDNA of ... Cited by 70 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Mok, H Cao, B Zinman, AJG Hanley, SB … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Several lines of evidence support a role for protein tyrosine phosphatase 1B
(PTP-1B) in metabolism, and specifically in insulin sensitivity and obesity. We
report the development of reagents for the amplification and sequencing of ... Cited by 63 - Related articles - BL Direct - All 6 versions
