G Jiang, Q Dallas-Yang, Z Li, D Szalkowski, F Liu, X … - Diabetes, 2002 - Am Diabetes Assoc Thiazolidinediones (TZDs), agonists of peroxisome proliferator-activated receptor-γ
(PPARγ), improve insulin sensitivity in vivo, and the mechanism remains largely unknown. In
this study, we showed that, in Zucker obese (fa/fa) rats, acute (1-day) treatment with both ... Cited by 64 - Related articles - BL Direct - All 5 versions
MM Meyer, K Levin, T Grimmsmann, N Perwitz, A Eirich … - Diabetes, 2002 - Am Diabetes Assoc We investigated whether the effect of troglitazone on glucose disposal is associated with altered
insulin signaling. Nondiabetic first-degree relatives of type 2 diabetic patients (age 30 ± 2
years, BMI 30 ± 1 kg/m 2 ; n = 20) were randomized in a double-blind manner to 3 months ... Cited by 28 - Related articles - BL Direct - All 4 versions
JK Kim, JJ Fillmore, O Gavrilova, L Chao, T … - Diabetes, 2003 - Am Diabetes Assoc To determine the role of adipocytes and the tissue-specific nature in the insulin sensitizing action
of rosiglitazone, we examined the effects of 3 weeks of rosiglitazone treatment on insulin signaling
and action during hyperinsulinemic-euglycemic clamps in awake A-ZIP/F-1 (fatless), fat- ... Cited by 60 - Related articles - BL Direct - All 5 versions
- ►endojournals.org JR Zierath, JW Ryder, T Doebber, J Woods, M Wu, J … - Endocrinology, 1998 - Endocrine Soc Thiazolidinedione (TZD) insulin sensitizers are specific agonists of peroxisome proliferator activated
receptor (PPAR) . However, their mechanism of action and the in vivo target tissue(s) that mediate
insulin sensitization remain poorly defined. Although PPAR messenger RNA expression ... Cited by 97 - Related articles - BL Direct - All 3 versions
D Kramer, R Shapiro, A Adler, E Bush, CM Rondinone - Metabolism, 2001 - Elsevier Thiazolidinediones (TZDs), a class of antidiabetic agents, are specific agonists of peroxisome
proliferator activator receptor (PPAR[gamma ]). However, their mechanisms of action, and the
in vivo target tissues that mediate insulin sensitization are not well understood. The aim of ... Cited by 44 - Related articles - BL Direct - All 7 versions
- ►fasebj.org ULF SMITH, S GOGG, A JOHANSSON, T OLAUSSON, … - The FASEB Journal, 2001 - FASEB Thiazolidinediones (TZD) improve insulin sensitivity in human as well as in different animal models
of insulin resistance and Type 2 diabetes. However, no clear link to the insulin signaling events
has been identified. Using differentiated 3T3-L1 adipocytes, we found that TZD rapidly ... Cited by 74 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org [PDF] AL Hevener, D Reichart, J Olefsky - Diabetes, 2000 - Am Diabetes Assoc Thiazolidinediones and exercise are both known to improve insulin action independently.
Therefore, we determined whether combined therapy could normalize insulin action in the Zucker
fatty (ZF) rat. Rats were fed troglitazone as a 0.2% food admixture over a 3-week exercise ... Cited by 53 - Related articles - BL Direct - All 4 versions
- ►endojournals.org JM Way, WW Harrington, KK Brown, WK Gottschalk, SS … - Endocrinology, 2001 - Endocrine Soc Peroxisome proliferator-activated receptor (PPAR ) agonists, including the glitazone class of
drugs, are insulin sensitizers that reduce glucose and lipid levels in patients with type 2 diabetes
mellitus. To more fully understand the molecular mechanisms underlying their therapeutic ... Cited by 236 - Related articles - All 2 versions
- ►nih.gov [PDF] G Jiang, Q Dallas-Yang, S Biswas, Z Li, BB … - Biochemical …, 2004 - pubmedcentral.nih.gov Biochem. J. (2004) 377, 339–346 (Printed in Great Britain) ... Rosiglitazone, an agonist of
peroxisome-proliferator-activated receptor γ ... (PPARγ), decreases inhibitory serine phosphorylation
of IRS1 in vitro ... Guoqiang JIANG1, Qing DALLAS-YANG, Subarna BISWAS, Zhihua LI ... Cited by 26 - Related articles - BL Direct - All 10 versions
LC Pickavance, RE Buckingham, JPH … - Diabetes Obesity and …, 2001 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 21 - Related articles - BL Direct - All 4 versions
