SA Hawley, AE Gadalla, GS Olsen, DG Hardie - Diabetes, 2002 - Am Diabetes Assoc Metformin, a drug widely used to treat type 2 diabetes, was recently shown to
activate the AMP-activated protein kinase (AMPK) in intact cells and in vivo. In
this study we addressed the mechanism for this effect. In intact cells, ... Cited by 241 - Related articles - BL Direct - All 4 versions
- ►jbc.org LGD Fryer, A Parbu-Patel, D Carling - Journal of Biological Chemistry, 2002 - ASBMB AMP-activated protein kinase (AMPK) is activated within the cell in response to
multiple stresses that increase the intracellular AMP:ATP ratio. Here we show
that incubation of muscle cells with the thiazolidinedione, rosiglitazone, ... Cited by 492 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org N Musi, MF Hirshman, J Nygren, M Svanfeldt, … - Diabetes, 2002 - Am Diabetes Assoc Metformin is an effective hypoglycemic drug that lowers blood glucose
concentrations by decreasing hepatic glucose production and increasing glucose
disposal in skeletal muscle; however, the molecular site of metformin ... Cited by 234 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] MR Owen, E Doran, AP Halestrap - Biochemical Journal, 2000 - pubmedcentral.nih.gov Although metformin is widely used for the treatment of non- insulin-dependent
diabetes, its mode of action remains unclear. Here we provide evidence that its
primary site of action is through a direct inhibition of complex 1 of the ... Cited by 223 - Related articles - BL Direct - All 7 versions
MY El-Mir, V Nogueira, E Fontaine, N Avéret, … - Journal of Biological Chemistry, 2000 - ASBMB We report here a new mitochondrial regulation occurring only in intact cells. We
have investigated the effects of dimethylbiguanide on isolated rat hepatocytes,
permeabilized hepatocytes, and isolated liver mitochondria. Addition of ... Cited by 136 - Related articles - BL Direct - All 3 versions
- ►nih.gov G Zhou, R Myers, Y Li, Y Chen, X Shen, J … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Metformin is a widely used drug for treatment of type 2 diabetes with no defined
cellular mechanism of action. Its glucose-lowering effect results from decreased
hepatic glucose production and increased glucose utilization. Metformin's ... Cited by 1104 - Related articles - BL Direct - All 7 versions
JM Corton, JG Gillespie, SA Hawley, DG … - European Journal of Biochemistry, 1995 - interscience.wiley.com The AMP-activated protein kinase (AMPK) is believed to protect cells against
environmental stress (eg heat shock) by switching off biosynthetic pathways, the
key signal being elevation of AMP. Identification of novel targets for the ... Cited by 483 - Related articles - BL Direct - All 8 versions
SA Hawley, M Davison, A Woods, SP Davies, … - Journal of Biological Chemistry, 1996 - ASBMB We have developed a sensitive assay for the AMP-activated protein kinase kinase,
the upstream component in the AMP-activated protein kinase cascade.
Phosphorylation and activation of the downstream kinase by the upstream ... Cited by 364 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] SC Stein, A Woods, NA Jones, MD Davison, D … - Biochemical Journal, 2000 - pubmedcentral.nih.gov The AMP-activated protein kinase (AMPK) cascade is activated by an increase in
the AMP\ATP ratio within the cell. AMPK is regulated allosterically by AMP and
by reversible phosphoryl- ation. Threonine-172 within the catalytic subunit ... Cited by 241 - Related articles - BL Direct - All 6 versions
A Woods, I Salt, J Scott, DG Hardie, D Carling - FEBS letters, 1996 - Elsevier The AMP-activated protein kinase (AMPK) is a heterotrimeric complex composed of
a catalytic subunit (a) and two regulatory subunits (β and γ). Two isoforms of
the catalytic subunit (αl and (α2) have been identified. We show here ... Cited by 145 - Related articles - All 5 versions
