- ►diabetesjournals.org TM Stulnig, U Oppermann, KR Steffensen, GU … - Diabetes, 2002 - Am Diabetes Assoc 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) converts inactive
corticosteroids into biologically active corticosteroids, thereby regulating the
local concentration of active glucocorticoids, such as cortisol. 11β-HSD-1 ... Cited by 87 - Related articles - BL Direct - All 5 versions
A Hermanowski-Vosatka, D Gerhold, SS Mundt, … - Biochemical and Biophysical Research …, 2000 - Elsevier 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) is an enzyme that converts
cortisone to the active glucocorticoid, cortisol. Cortisol–cortisone
interconversion plays a key role in the regulation of glucose metabolism, ... Cited by 70 - Related articles - BL Direct - All 7 versions
G Cao, Y Liang, CL Broderick, BA Oldham, TP … - Journal of Biological Chemistry, 2003 - ASBMB The oxysterol receptors LXR (liver X receptor)-α and LXRβ are nuclear
receptors that play a key role in regulation of cholesterol and fatty acid
metabolism. We found that LXRs also play a significant role in glucose ... Cited by 160 - Related articles - BL Direct - All 4 versions
- ►jbc.org J Berger, M Tanen, A Elbrecht, A Hermanowski … - Journal of Biological Chemistry, 2001 - ASBMB Peroxisome proliferator-activated receptor- (PPAR ) has been shown to play an
important role in the regulation of expression of a subclass of adipocyte genes
and to serve as the molecular target of the thiazolidinedione (TZD) and ... Cited by 142 - Related articles - BL Direct - All 3 versions
- ►endojournals.org O Paulmyer-Lacroix, S Boullu, C Oliver, MC … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Glucocorticoids play an important role in determining adipose tissue metabolism
and distribution. Patients with Cushing's syndrome or receiving corticosteroid
therapy develop a reversible visceral obesity. In obese patients, although ... Cited by 156 - Related articles - BL Direct - All 4 versions
- ►endojournals.org NM Morton, L Ramage, JR Seckl - Endocrinology, 2004 - Endocrine Soc The enzyme 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1) amplifies
intracellular glucocorticoid action in vivo. 11ß-HSD-1 activity is increased in
adipose tissues of obese humans and genetically obese rodents, providing a ... Cited by 45 - Related articles - BL Direct - All 5 versions
- ►aspetjournals.org TM Stulnig, KR Steffensen, H Gao, M Reimers … - Molecular pharmacology, 2002 - ASPET Liver X receptor (LXR) and LXR are nuclear oxysterol receptors whose biological
function has so far been elucidated only with respect to cholesterol and lipid
metabolism. To expose novel biological roles for LXRs, we performed ... Cited by 89 - Related articles - BL Direct - All 3 versions
- ►jbc.org LJS Williams, V Lyons, I MacLeod, V Rajan, … - Journal of Biological Chemistry, 2000 - ASBMB Glucocorticoid action within individual cells is potently modulated by 11
-hydroxysteroid dehydrogenase (11 -HSD), which, by interconverting active and
inert glucocorticoids, determines steroid access to receptors. Type 1 11 ... Cited by 69 - Related articles - BL Direct - All 3 versions
NM Morton, MC Holmes, C Fievet, B Staels, A … - Journal of Biological Chemistry, 2001 - ASBMB Excess tissue glucocorticoid action may underlie the dyslipidemia, insulin
resistance, and impaired glucose tolerance of the metabolic syndrome.
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD-1) catalyzes conversion ... Cited by 213 - Related articles - BL Direct - All 3 versions
