- ►diabetesjournals.org BA O'Brien, Y Huang, X Geng, JP Dutz, DT … - Diabetes, 2002 - Am Diabetes Assoc Macrophages limit inflammatory responses by clearing apoptotic cells.
Deficiencies in apoptotic cell phagocytosis have been linked to autoimmunity. In
this study, we determined the efficiency with which macrophages from ... Cited by 67 - Related articles - BL Direct - All 5 versions
BA O'Brien, WE Fieldus, CJ Field, DT … - Cell death and differentiation, 2002 - ncbi.nlm.nih.gov The kinetics of beta-cell death in neonatal diabetes-prone (BBdp) and
diabetes-resistant (BBdr) BioBreeding rats was investigated using both direct
(histochemical) and indirect (mathematical modelling) techniques. In both ... Cited by 27 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org [PDF] JD Trudeau, JP Dutz, E Arany, DJ Hill, WE … - Diabetes, 2000 - Am Diabetes Assoc In neonatal rodents, the -cell mass undergoes a phase of remodeling that
includes a wave of apoptosis. Using both mathematical modeling and histochemical
detec- tion methods, we have demonstrated that -cell apo- ptosis is ... Cited by 153 - Related articles - BL Direct - All 4 versions
S Charre, JG Rosmalen, C Pelegri, V Alves, … - Histology and histopathology, 2002 - ncbi.nlm.nih.gov Dendritic cell (DC), macrophage (Mphi) and lymphocyte infiltrations have been
observed in normal human perinatal pancreata, but have never been investigated
so early in control mice. In type 1 diabetes-prone NOD mice, these cells ... Cited by 33 - Related articles - BL Direct - All 3 versions
- ►ubc.ca [PDF] AFM Marée, M Komba, C Dyck, M Łabęcki, DT … - Journal of theoretical biology, 2005 - Elsevier Macrophages from animals prone to autoimmune (type 1) diabetes differ from those
of diabetes-resistant animals in processing and clearing apoptotic cells. Using
in vitro time-course assays of the number of engulfed apoptotic cells ... Cited by 11 - Related articles - All 8 versions
K Stoffels, L Overbergh, A Giulietti, A Kasran … - Journal of Autoimmunity, 2004 - Elsevier During the development of type 1 diabetes, pancreatic beta-cells are subject to
an immune attack, leading to their apoptotic or necrotic cell death. Apoptotic
beta-cells are also present during periods of tissue remodeling, such as in ... Cited by 17 - Related articles - All 5 versions
BA O'Brien, X Geng, CH Orteu, Y Huang, M … - Journal of Autoimmunity, 2006 - Elsevier Deficiencies in apoptotic cell clearance have been linked to autoimmunity. Here
we examined the time-course of peritoneal macrophage phagocytosis of dying cells
following the direct injection of apoptotic thymocytes into the peritoneum ... Cited by 27 - Related articles - All 4 versions
- ►cell.com S Hugues, E Mougneau, W Ferlin, D Jeske, P … - Immunity, 2002 - Elsevier Crosspresentation of self-antigens by antigen-presenting cells is critical for
the induction of peripheral tolerance. As apoptosis facilitates the entry of
antigens into the crosspresentation pathway, we sought to prevent the ... Cited by 109 - Related articles - BL Direct - All 7 versions
- ►ubc.ca [PDF] AFM Marée, R Kublik, DT Finegood, L … - Philosophical Transactions of the Royal Society A: …, 2006 - rsta.royalsocietypublishing.org A wave of apoptosis (programmed cell death) occurs normally in pancreatic
β-cells of newborn mice. We previously showed that macrophages from non-obese
diabetic (NOD) mice become activated more slowly and engulf apoptotic cells ... Cited by 8 - Related articles - All 12 versions
JD Piganelli, T Martin, K Haskins - Diabetes-American Diabetes Association, 1998 - Am Diabetes Assoc IDDM results from the destruction of pancreatic -cells by autoreactive T-cells
that appear to avoid deletion early in development, possibly due to improper
interac- tion with antigen-presenting cells (APCs) resident in the thymus ... Cited by 57 - Related articles - BL Direct - All 4 versions
