S Yoshida, Y Kajimoto, T Yasuda, H Watada, … - Diabetes, 2002 - Am Diabetes Assoc A homeodomain containing transcription factor PDX-1 can induce
β-cell–specific gene expressions in some non–β-cells and may therefore be
useful for future diabetes gene/cell therapy. Among the potential target ... Cited by 91 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org H Kojima, T Nakamura, Y Fujita, A Kishi, M … - Diabetes, 2002 - Am Diabetes Assoc Immature rat intestinal stem cells (IEC-6) given the ability to express the
transcription factor, pancreatic duodenal homeobox 1 (Pdx-1), yielded YK cells.
Although these cells produced multiple enteroendocrine hormones, they did ... Cited by 110 - Related articles - BL Direct - All 5 versions
H Kojima, M Fujimiya, K Matsumura, P … - Nature medicine, 2003 - nature.com To explore induced islet neogenesis in the liver as a strategy for the treatment
of diabetes, we used helper-dependent adenovirus (HDAD) to deliver the
pancreatic duodenal homeobox-1 gene (Ipf1; also known as Pdx-1) to ... Cited by 232 - Related articles - BL Direct - All 3 versions
T Miyatsuka, H Kaneto, Y Kajimoto, S Hirota, … - Biochemical and Biophysical Research …, 2003 - Elsevier To date, the potency of pancreatic and duodenal homeobox gene 1 (PDX-1) in
inducing differentiation into insulin-producing cells has been demonstrated in
some cells and tissues. In order to carry out efficient screening of ... Cited by 46 - Related articles - All 6 versions
S Ferber, A Halkin, H Cohen, I Ber, Y Einav, I … - Nature medicine, 2000 - ntbiomol.unibe.ch Insulin gene expression is restricted to islet β cells of the mam- malian
pancreas through specific control mechanisms mediated in part by specific
transcription factors1,2. The protein encoded by the pancreatic and ... Cited by 385 - Related articles - View as HTML - BL Direct - All 3 versions
H Taniguchi, E Yamato, F Tashiro, H Ikegami, … - Gene Therapy, 2003 - nature.com -cell neogenesis is expected to provide a new therapy for diabetes. Numerous
studies have demonstrated that transcriptional regulation involving pdx-1 is
essential for endocrine neogenesis in vivo and in vitro. Therefore, it is ... Cited by 56 - Related articles - BL Direct - All 4 versions
- ►montreal-diabetes-research-center.org [PDF] ME Horb, CN Shen, D Tosh, JMW Slack - Current Biology, 2003 - Elsevier Results: We show that a modified form of Pdx1, carrying the VP16 transcriptional
activation domain, can cause conversion of liver to pancreas, both in vivo and
in vitro. Transgenic Xenopus tadpoles carrying the construct ... Cited by 177 - Related articles - All 17 versions
[CITATION] Activation of the hexosamine pathway leads to deterioration of pancreatic β-cell function by …
- ►jbc.org H Kaneto, J Miyagawa, Y Kajimoto, K … - Journal of Biological Chemistry, 1997 - ASBMB The development of the pancreas appears to be regulated by various growth
factors. We report here the expression of heparin-binding epidermal growth
factor (EGF)-like growth factor (HB-EGF) in the developing pancreas. ... Cited by 49 - Related articles - BL Direct - All 4 versions
