C Andreolas, G da Silva Xavier, F Diraison, C Zhao, A … - Diabetes, 2002 - Am Diabetes Assoc Acetyl-CoA carboxylase I (ACCI) is a key lipogenic enzyme whose induction in islet β-cells may
contribute to glucolipotoxicity. Here, we provide evidence that enhanced insulin release plays
an important role in the activation of this gene by glucose. Glucose (30 vs. 3 mmol/l) ... Cited by 48 - Related articles - BL Direct - All 5 versions
H Wang, P Maechler, PA Antinozzi, L Herrero, KA … - Journal of Biological …, 2003 - ASBMB Accumulation of lipids in non-adipose tissues is often associated with Type 2 diabetes and its
complications. Elevated expression of the lipogenic transcription factor, sterol regulatory element
binding protein-1c (SREBP-1c), has been demonstrated in islets and liver of diabetic ... Cited by 72 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] F Diraison, L Parton, P Ferré, F Foufelle, CP … - Biochemical …, 2004 - pubmedcentral.nih.gov Accumulation of intracellular lipid by pancreatic islet β-cells has been proposed to inhibit normal
glucose-regulated insulin secretion ('glucolipotoxicity'). In the present study, we determine whether
over-expression in rat islets of the lipogenic transcription factor SREBP1c ... Cited by 55 - Related articles - BL Direct - All 8 versions
- ►endojournals.org T Yamashita, K Eto, Y Okazaki, S Yamashita, T … - Endocrinology, 2004 - Endocrine Soc Triglyceride (TG) accumulation in pancreatic ß-cells is thought to be associated with impaired
insulin secretory response to glucose (lipotoxicity). To better understand the mechanism of the
impaired insulin secretory response to glucose in ß-cell lipotoxicity, we overexpressed a ... Cited by 51 - Related articles - BL Direct - All 3 versions
A Takahashi, K Motomura, T Kato, T Yoshikawa, Y … - Diabetes, 2005 - Am Diabetes Assoc Influx of excess fatty acids and the resultant accumulation of intracellular triglycerides are linked
to impaired insulin secretion and action in the pathogenesis of type 2 diabetes. Sterol regulatory
element-binding protein (SREBP)-1c is a transcription factor that controls cellular ... Cited by 43 - Related articles - All 5 versions
MB Sandberg, J Fridriksson, L Madsen, V Rishi, C … - Molecular and cellular …, 2005 - Elsevier Here we investigate the role of sterol-regulatory element binding proteins in glucose-induced
lipogenesis in the pancreatic β-cell line INS-1E. We show that glucose induces SREBP-1c expression
and SREBP-1 activity independent of insulin secretion and signaling. Using adenoviral ... Cited by 17 - Related articles - All 3 versions
- ►diabetesjournals.org K Eto, T Yamashita, J Matsui, Y Terauchi, M Noda, T … - Diabetes, 2002 - Am Diabetes Assoc Triacylglyceride (TG) accumulation in pancreatic ß-cells is associated with impaired insulin
secretion, which is called lipotoxicity. To gain a better understanding of the pathophysiology
of lipotoxicity, we generated three models of dysregulated fatty acid metabolism in ß-cells. ... Cited by 38 - Related articles - BL Direct - All 3 versions
G da Silva Xavier, A Varadi, EK Ainscow, GA … - Journal of Biological …, 2000 - ASBMB Increases in glucose concentration control the transcription of the preproinsulin (PPI) gene and
several other genes in the pancreatic islet β-cell. Although recent data have demonstrated that
secreted insulin may regulate the PPI gene (Leibiger, IB, Leibiger, B., Moede, T., and ... Cited by 55 - Related articles - BL Direct - All 4 versions
D Flamez, V Berger, M Kruhøffer, T Orntoft, D Pipeleers, … - Diabetes, 2002 - Am Diabetes Assoc The molecular mechanisms mediating acute regulation of insulin release by glucose are partially
known. The process involves at least two pathways that can be discriminated on basis of their
(in)dependence of closure of ATP-sensitive potassium (K + ATP ) channels. The ... Cited by 71 - Related articles - BL Direct - All 5 versions
[CITATION] Glucose-induced ATP microdomains in single islet beta-cells
