- ►pubget.com [PDF] CS Lee, NJ Sund, MZ Vatamaniuk, FM … - Diabetes, 2002 - Am Diabetes Assoc Differentiation of early foregut endoderm into pancreatic endocrine and exocrine
cells depends on a cascade of gene activation events controlled by various
transcription factors. Prior in vitro analysis has suggested that the ... Cited by 77 - Related articles - BL Direct - All 5 versions
- ►ukpmc.ac.uk NJ Sund, MZ Vatamaniuk, M Casey, SL Ang, … - Genes & Development, 2001 - genesdev.cshlp.org We have used conditional gene ablation to uncover a dramatic and unpredicted
role for the winged-helix transcription factor Foxa2 (formerly HNF-3β) in
pancreatic β-cell differentiation and metabolism. Mice that lack Foxa2 ... Cited by 100 - Related articles - BL Direct - All 6 versions
- ►nih.gov KA Lantz, MZ Vatamaniuk, JE Brestelli, JR … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig The regulation of insulin secretion by pancreatic β cells is perturbed in
several diseases, including adult-onset (type 2) diabetes and persistent
hyperinsulinemic hypoglycemia of infancy (PHHI). The first mouse model for ... Cited by 68 - Related articles - BL Direct - All 8 versions
H Wang, BR Gauthier, KA Hagenfeldt- … - Journal of Biological Chemistry, 2002 - ASBMB The transcription factor Foxa2 is implicated in blood glucose homeostasis.
Conditional expression of Foxa2 or its dominant-negative mutant DN-Foxa2 in
INS-1 cells reveals that Foxa2 regulates the expression of genes important ... Cited by 45 - Related articles - BL Direct - All 5 versions
E Ben-Shushan, S Marshak, M Shoshkes, E … - Journal of Biological Chemistry, 2001 - ASBMB The PDX-1 transcription factor plays a key role in pancreas development.
Although expressed in all cells at the early stages, in the adult it is mainly
restricted to the -cell. To characterize the regulatory elements and ... Cited by 65 - Related articles - BL Direct - All 4 versions
K Gerrish, M Gannon, D Shih, E Henderson, M … - Journal of Biological Chemistry, 2000 - ASBMB To identify potential transactivators ofpdx-1, we sequenced approximately 4.5
kilobases of the 5′ promoter region of the human and chicken homologs,
assuming that sequences conserved with the mouse gene would contain ... Cited by 113 - Related articles - BL Direct - All 3 versions
KA Lantz, KH Kaestner - Clinical Science, 2005 - cs.portlandpress.com The forkhead gene family, named after the founding gene member in Drosophila, is
characterized by a unique DNA-binding domain. This so-called forkhead box
encodes a winged-helix DNA-binding motif, the name of which describes the ... Cited by 34 - Related articles - View as HTML - All 9 versions
- ►nih.gov [PDF] S Sharma, US Jhala, T Johnson, K Ferreri, J … - Molecular and Cellular Biology, 1997 - Am Soc Microbiol Page 1. M OLECULAR AND C ELLULAR B IOLOGY , 0270-7306/97/$04.00 0 May 1997, p.
2598–2604 Vol. 17, No. 5 Copyright 1997, American Society for Microbiology ... Cited by 96 - Related articles - BL Direct - All 5 versions
- ►nih.gov DQ Shih, M Navas, S Kuwajima, SA Duncan, M … - Proceedings of the National Academy of Sciences of …, 1999 - National Acad Sciences Hepatocyte nuclear factors 3 (HNF-3) belong to an evolutionarily conserved
family of transcription factors that are critical for diverse biological
processes such as development, differentiation, and metabolism. To study ... Cited by 78 - Related articles - BL Direct - All 8 versions
