- ►diabetesjournals.org R Bottino, AN Balamurugan, S Bertera, M … - Diabetes, 2002 - Am Diabetes Assoc The most commonly used technical approach to isolate human pancreatic islets
intended for allotransplants generates a product that is hampered by mechanical
and chemical insults, which dramatically reduce the mass of viable and ... Cited by 79 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in
the islets of Langerhans involving activation of apoptosis and necrosis and the
production of proinflammatory molecules that negatively influence islet ... Cited by 72 - Related articles - BL Direct - All 4 versions
S Bertera, ML Crawford, AM Alexander, GD … - Diabetes, 2003 - Am Diabetes Assoc Islet transplantation is a promising cure for diabetes. However, inflammation,
allorejection, and recurrent autoimmune damage all may contribute to early graft
loss. Pancreatic islets express lower levels of antioxidant genes than most ... Cited by 68 - Related articles - BL Direct - All 4 versions
JD Piganelli, SC Flores, C Cruz, J Koepp, I … - Diabetes, 2002 - Am Diabetes Assoc We present here the first report of a metalloporphyrin-based antioxidant that
can prevent or delay the onset of autoimmune diabetes. Type 1 diabetes is an
autoimmune process whereby T-cells recognize pancreatic β-cell antigens ... Cited by 84 - Related articles - BL Direct - All 4 versions
S Paraskevas, D Maysinger, R Wang, WP … - Pancreas, 2000 - journals.lww.com Purified islet allografts have largely failed to maintain long-term glucose
homeostasis in human recipients, and the reasons for this are unclear. It is
noteworthy, however, that islet isolation destroys or removes cellular and ... Cited by 92 - Related articles - BL Direct - All 4 versions
AN Balamurugan, Y Chang, JJ Fung, M Trucco … - American Journal of Transplantation, 2003 - interscience.wiley.com Worldwide growing interest in reproducing the result of the Edmonton protocol in
islet transplantation trials poses the problem of paucity of donors to supply
sufficient amount of islets for clinical use. Improved outcomes include ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►diabetesresearch.org [PDF] A Pileggi, RD Molano, T Berney, P Cattan, C … - Diabetes, 2001 - Am Diabetes Assoc Transplantation of islets of Langerhans represents a viable therapeutic approach
for the treatment of type 1 diabetes. Unfortunately, transplanted islets are
susceptible to allogeneic recognition and rejection, recurrence of ... Cited by 165 - Related articles - BL Direct - All 5 versions
L Rosenberg, R Wang, S Paraskevas, D … - Surgery, 1999 - Elsevier Successful islet transplantation with documented normoglycemia in the absence of
exogenous insulin therapy is reported in the International Islet Transplant
Registry. 1 This summary of adult islet allografts in patients with insulin- ... Cited by 86 - Related articles - BL Direct - All 8 versions
J Avila, B Barbaro, A Gangemi, T Romagnoli, … - American Journal of Transplantation, 2005 - ccmjournal.org Oxidative stress during islet isolation induces a cascade of events injuring
islets and hampering islet engraftment. This study evaluated islet isolation and
transplantation outcomes after intra-ductal glutamine administration. Human ... Cited by 14 - Related articles - BL Direct - All 5 versions
AN Balamurugan, J He, F Guo, DB Stolz, S … - American Journal of Transplantation, 2005 - interscience.wiley.com The isolation process exposes human pancreatic islets to exogenous isolation
enzymes. Exposure to these enzymes, as a result of intraductal injection in the
pancreas or simple contact of islets with enzyme components, causes ... Cited by 20 - Related articles - BL Direct - All 4 versions
