ME Young, PH Guthrie, P Razeghi, B Leighton, … - Diabetes, 2002 - Am Diabetes Assoc We investigated whether decreased responsiveness of the heart to physiological
increases in fatty acid availability results in lipid accumulation and lipotoxic
heart disease. Lean and obese Zucker rats were either fed ad libitum or ... Cited by 108 - Related articles - BL Direct - All 5 versions
- ►fasebj.org S Sharma, JV Adrogue, L Golfman, I Uray, J … - The FASEB Journal, 2004 - FASEB In animal models of lipotoxicity, accumulation of triglycerides within
cardiomyocytes is associated with contractile dysfunction. However, whether
intramyocardial lipid deposition is a feature of human heart failure ... Cited by 140 - Related articles - BL Direct - All 3 versions
- ►nih.gov BN Finck, X Han, M Courtois, F Aimond, JM … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences To explore the role of peroxisome proliferator-activated receptor α
(PPARα)-mediated derangements in myocardial metabolism in the pathogenesis of
diabetic cardiomyopathy, insulinopenic mice with PPARα deficiency (PPARα ... Cited by 209 - Related articles - BL Direct - All 12 versions
PK Mazumder, BT O'Neill, MW Roberts, J … - Diabetes, 2004 - Am Diabetes Assoc Diabetes alters cardiac substrate metabolism. The cardiac phenotype in
insulin-resistant states has not been comprehensively characterized. The goal of
these studies was to determine whether the hearts of leptin-deficient ... Cited by 99 - Related articles - BL Direct - All 6 versions
- ►physiology.org P Wang, SG Lloyd, H Zeng, A Bonen, JC … - American Journal of Physiology- Heart and Circulatory …, 2005 - Am Physiological Soc The goal of this study was to determine whether changes in cardiac metabolism in
Type 2 diabetes are associated with contractile dysfunction or impaired response
to ischemia. Hearts from Zucker diabetic fatty (ZDF) and lean control rats ... Cited by 39 - Related articles - BL Direct - All 4 versions
C Christoffersen, E Bollano, MLS Lindegaard, … - Endocrinology, 2003 - Endocrine Soc Obesity may confer cardiac dysfunction due to lipid accumulation in
cardiomyocytes. To test this idea, we examined whether obese ob/ob mice display
heart lipid accumulation and cardiac dysfunction. Ob/ob mouse hearts had ... Cited by 110 - Related articles - BL Direct - All 4 versions
- ►pnas.org YT Zhou, P Grayburn, A Karim, M Shimabukuro … - Proceedings of the National Academy of Sciences, 2000 - National Acad Sciences To determine the mechanism of the cardiac dilatation and reduced contractility
of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed
chemically and morphologically. TG was high because of underexpression of ... Cited by 561 - Related articles - All 9 versions
- ►physiology.org DD Belke, TS Larsen, EM Gibbs, DL Severson - American Journal of Physiology- Endocrinology And …, 2000 - Am Physiological Soc Contractile function and substrate metabolism were characterized in perfused
hearts from genetically diabetic C57BL/KsJ-lepr db /lepr db (db/db) mice and
their non-diabetic lean littermates. Contractility was assessed in working ... Cited by 183 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org [PDF] HC Chiu, A Kovacs, RM Blanton, X Han, M … - Circulation research, 2005 - Am Heart Assoc Kluwer Health, 351 West Camden Street, Baltimore, MD 21202-2436. Phone:
410-528-4050. Permissions: Permissions & Rights Desk, Lippincott Williams &
Wilkins, a division of Wolters ... Transgenic Expression of Fatty Acid ... Cited by 142 - Related articles - All 8 versions
- ►nih.gov HC Chiu, A Kovacs, DA Ford, FF Hsu, R Garcia, … - Journal of Clinical Investigation, 2001 - Am Soc Clin Investig Inherited and acquired cardiomyopathies are associated with marked intracellular
lipid accumulation in the heart. To test the hypothesis that mismatch between
myocardial fatty acid uptake and utilization leads to the accumulation of ... Cited by 297 - Related articles - BL Direct - All 7 versions
