R Pop-Busui, V Marinescu, C Van Huysen, F Li … - Diabetes, 2002 - Am Diabetes Assoc Alterations in cyclooxygenase (COX) pathway activity have been implicated in the
pathogenesis of experimental diabetic neuropathy (EDN). These studies explore
the relationships between COX-mediated and acetyl-l-carnitine ... Cited by 39 - Related articles - BL Direct - All 5 versions
SI Yamagishi, K Uehara, S Otsuki, S … - Journal of neurochemistry, 2003 - interscience.wiley.com To explore the relationship between polyol pathway and protein kinase C (PKC),
we examined PKC activities and expressions of PKC isoforms separately in
endoneurial and vessel-rich epineurial tissues in diabetic mice transgenic ... Cited by 25 - Related articles - BL Direct - All 4 versions
Z Song, DTW Fu, YS Chan, S Leung, SSM … - Molecular and Cellular Neuroscience, 2003 - Elsevier To further understand the role of aldose reductase (AR) in the etiology of
diabetic neuropathy, we generated transgenic mice that overexpress AR
specifically in the Schwann cells under the control of the rat myelin ... Cited by 52 - Related articles - All 3 versions
IG Obrosova, L Fathallah, MJ Stevens - Experimental Neurology, 2001 - Elsevier Oxidative stress has a key role in the pathogenesis of diabetic complications.
We have previously reported that taurine (T), which is known to counteract
oxidative stress in tissues (lens, kidney, retina) of diabetic rats, ... Cited by 81 - Related articles - BL Direct - All 7 versions
- ►umich.edu [PDF] AP Kellogg, R Pop-Busui - Antioxidants & Redox Signaling, 2005 - liebertonline.com D IABETIC PERIPHERAL NEUROPATHY (DPN) affects most patients with diabetes and is
the leading cause of non- traumatic lower limb amputations, accounting for
85,000 amputations per year in the US To date, besides a tight glycemic ... Cited by 18 - Related articles - BL Direct - All 4 versions
L Hounsom, R Corder, J Patel, DR Tomlinson - Diabetologia, 2001 - Springer Oxidative stress has been suggested to be a causal factor of diabetic
complications [1±3]. Diabetes com- promises natural antioxidant defence
systems, lower- ing tissue GSH (reduced glutathione), ascorbic acid, ... Cited by 31 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org S Yagihashi, SI Yamagishi, R Wada, M Baba, … - Brain, 2001 - Oxford Univ Press The present study was designed to examine the effect of aldose reductase (AR)
overexpression on the development of diabetic neuropathy by using mice
transgenic for human AR. At 8 weeks of age, transgenic mice (Tg) and non- ... Cited by 65 - Related articles - BL Direct - All 4 versions
IG Obrosova, F Li, OI Abatan, MA Forsell, K … - Diabetes, 2004 - Am Diabetes Assoc Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic
neuropathy, but the mechanisms remain unidentified. Here we provide evidence
that poly(ADP-ribose) polymerase (PARP) activation, a downstream effector ... Cited by 88 - Related articles - BL Direct - All 10 versions
MJ Stevens, SA Lattimer, EL Feldman, ED … - Metabolism, 1996 - Elsevier Defective metabolism of long-chain fatty acids and/or their accumulation in
nerve may impair nerve function in diabetes by altering plasma or mitochondrial
membrane integrity and perturbing intracellular metabolism and energy ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►inotekcorp.com [PDF] F Li, C Szabo, P Pacher, GJ Southan, OI … - Diabetologia, 2004 - Springer Aims/hypothesis. Poly(ADP-ribose) polymerase acti- vation depletes NAD + and
high-energy phosphates, activates protein kinase C, and affects gene expression
in various tissues. This study was designed to charac- terise the effects ... Cited by 38 - Related articles - BL Direct - All 11 versions
