MM Meyer, K Levin, T Grimmsmann, N Perwitz, … - Diabetes, 2002 - Am Diabetes Assoc We investigated whether the effect of troglitazone on glucose disposal is
associated with altered insulin signaling. Nondiabetic first-degree relatives of
type 2 diabetic patients (age 30 ± 2 years, BMI 30 ± 1 kg/m 2 ; n = 20) ... Cited by 28 - Related articles - BL Direct - All 4 versions
K Levin, O Hother-Nielsen, JE Henriksen, H … - Diabetes care, 2004 - Am Diabetes Assoc RESULTS—Twelve relatives received troglitazone and 12 placebo (aged 30.8 ±
2.0 vs. 30.3 ± 1.6 years, BMI 29.6 ± 0.8 vs. 30.5 ± 1.3 kg/m 2 ; means ±
SE). Area under the curve (AUC) for plasma glucose at the second OGTT was ... Cited by 11 - Related articles - BL Direct - All 6 versions
YB Kim, TP Ciaraldi, A Kong, D Kim, N Chu, … - Diabetes, 2002 - Am Diabetes Assoc Insulin stimulation of phosphatidylinositol (PI) 3-kinase activity is defective
in skeletal muscle of type 2 diabetic individuals. We studied the impact of
antidiabetic therapy on this defect in type 2 diabetic subjects who failed ... Cited by 68 - Related articles - BL Direct - All 4 versions
G Jiang, Q Dallas-Yang, Z Li, D Szalkowski, … - Diabetes, 2002 - Am Diabetes Assoc Thiazolidinediones (TZDs), agonists of peroxisome proliferator-activated
receptor-γ (PPARγ), improve insulin sensitivity in vivo, and the mechanism
remains largely unknown. In this study, we showed that, in Zucker obese ... Cited by 64 - Related articles - BL Direct - All 5 versions
K Hojlund, H Beck-Nielsen - Current Diabetes Reviews, 2006 - ingentaconnect.com Abstract: Insulin resistance in skeletal muscle is a major hallmark of type 2
diabetes and an early detectable abnormality in the development of this disease.
The cellular mechanisms of insulin resistance include impaired ... Cited by 7 - Related articles - BL Direct - All 2 versions
[CITATION] Thiazolidinediones (PPAR-agonists) but not PPAR-agonists increase IRS-2 gene expression …
- ►nih.gov [PDF] G Jiang, Q Dallas-Yang, S Biswas, Z Li, BB … - Biochemical Journal, 2004 - pubmedcentral.nih.gov Biochem. J. (2004) 377, 339–346 (Printed in Great Britain) ... Rosiglitazone,
an agonist of peroxisome-proliferator-activated receptor γ ... (PPARγ),
decreases inhibitory serine phosphorylation of IRS1 in vitro Cited by 26 - Related articles - BL Direct - All 10 versions
- ►endojournals.org L Delahaye, I Mothe-Satney, MG Myers, MF … - Endocrinology, 1998 - Endocrine Soc Serine and threonine phosphorylation has been shown to down-regulate insulin
signaling at multiple steps, including the receptor and downstream molecules
such as insulin receptor substrate-1 (IRS-1). To further address the ... Cited by 40 - Related articles - BL Direct - All 5 versions
K Højlund, J Frystyk, K Levin, A Flyvbjerg, … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: Circulating levels of adipo- nectin are negatively
associated with multiple indices of insulin resistance, and the concentration is
reduced in humans with insulin resistance and type 2 diabetes. However, the ... Cited by 13 - Related articles - BL Direct - All 3 versions
- ►fasebj.org ULF SMITH, S GOGG, A JOHANSSON, T … - The FASEB Journal, 2001 - FASEB Thiazolidinediones (TZD) improve insulin sensitivity in human as well as in
different animal models of insulin resistance and Type 2 diabetes. However, no
clear link to the insulin signaling events has been identified. Using ... Cited by 74 - Related articles - BL Direct - All 2 versions
