KJ Way, K Isshiki, K Suzuma, T Yokota, D … - Diabetes, 2002 - Am Diabetes Assoc Protein kinase C (PKC) β isoform activity is increased in myocardium of
diabetic rodents and heart failure patients. Transgenic mice overexpressing
PKCβ2 (PKCβ2Tg) in the myocardium exhibit cardiomyopathy and cardiac ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org R Candido, JM Forbes, MC Thomas, V Thallas, … - Circulation research, 2003 - Am Heart Assoc The formation of advanced glycation end products (AGEs) on extracellular matrix
components leads to accelerated increases in collagen cross linking that
contributes to myocardial stiffness in diabetes. This study determined the ... Cited by 211 - Related articles - BL Direct - All 8 versions
H Ohnishi, T Oka, S Kusachi, T Nakanishi, K … - Journal of molecular and cellular cardiology, 1998 - Elsevier Connective tissue growth factor (CTGF), a 36- to 38-kDa peptide, is selectively
induced by transforming growth factor-βand has been suggested to contribute to
tissue repair. To test the hypothesis that CTGF is expressed in myocardial ... Cited by 73 - Related articles - BL Direct - All 5 versions
- ►endojournals.org SM Twigg, Z Cao, SV MCLennan, WC Burns, … - Endocrinology, 2002 - Endocrine Soc The aim of this study was to determine whether aminoguanidine (AG), an inhibitor
of advanced glycation, prevents expression of the profibrotic cytokine,
connective tissue growth factor (CTGF), as well as accumulation of the ... Cited by 112 - Related articles - BL Direct - All 4 versions
- ►shouxi.net Z He, KJ Way, E Arikawa, E Chou, DM Opland, … - Journal of Biological Chemistry, 2005 - ASBMB Protein kinase C (PKC) and angiotensin II (AngII) can regulate cardiac function
in pathological conditions such as in diabetes or ischemic heart disease. We
have reported that expression of connective tissue growth factor (CTGF) is ... Cited by 38 - Related articles - All 6 versions
D Qin, B Huang, L Deng, H El-Adawi, K … - Biochemical and Biophysical Research …, 2001 - Elsevier Type I diabetic cardiomyopathy has consistently been shown to be associated with
decrease of repolarising K + currents, but the mechanisms responsible for the
decrease are not well defined. We investigated the streptozotocin (STZ) rat ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►uoa.gr [PDF] TJ Kemp, IK Aggeli, PH Sugden, A Clerk - Journal of molecular and cellular cardiology, 2004 - Elsevier Cardiac hypertrophy is associated with hypertrophic growth of cardiac myocytes
and increased fibrosis. Much is known of the stimuli which promote myocyte
hypertrophy and the changes associated with the response, but the links ... Cited by 32 - Related articles - All 7 versions
- ►endojournals.org SM Twigg, MM Chen, AH Joly, SD Chakrapani, … - Endocrinology, 2001 - Endocrine Soc Expansion of extracellular matrix with fibrosis occurs in many tissues as part
of the end-organ complications in diabetes, and advanced glycosylation end
products (AGE) are implicated as one causative factor in diabetic tissue ... Cited by 100 - Related articles - BL Direct - All 5 versions
- ►physiology.org M Guo, MH Wu, F Korompai, SY Yuan - Physiological genomics, 2003 - Am Physiological Soc The protein kinase C (PKC) pathway has recently been recognized as an important
mechanism in the development of diabetic complications including cardiomyopathy
and angiopathy. Although an increase in PKC kinase activity has been ... Cited by 48 - Related articles - BL Direct - All 4 versions
MM Chen, A Lam, JA Abraham, GF Schreiner, … - Journal of Molecular and Cellular Cardiology, 2000 - Elsevier Connective tissue growth factor (CTGF) is a cysteine-rich protein induced by
transforming growth factor beta (TGF- β) in connective tissue cells. CTGF can
trigger many of the cellular processes underlying fibrosis, such as cell ... Cited by 202 - Related articles - BL Direct - All 6 versions
